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Current Bioinformatics

Editor-in-Chief

ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

A Review of the Computational Methods for Identifying the Over- Annotated Genes and Missing Genes in Microbial Genomes

Author(s): Jia-Feng Yu, Zhen-Zhen Guo, Xiao Sun and Ji-Hua Wang

Volume 9, Issue 2, 2014

Page: [147 - 154] Pages: 8

DOI: 10.2174/1574893608999140109120612

Price: $65

Abstract

More and more studies indicate that the issue of protein-coding gene finding in microbial genomes is far from thoroughly solved and the annotation quality has been questioned continuously in the past several years. In this paper, we summarize the computational methods for identifying the over-annotated genes and missing genes, and provide perspective for prospective gene finding works.

Keywords: Microbial genome, missing gene, over-annotated gene, protein-coding gene, re-annotation.


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