Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology

Title:Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology

Volume: 11 Issue: 2

Author(s): Mukesh Chandra Joshi, Krishan Kumar and Vikrant Kumar

Affiliation:

Keywords: Clinical trial, glioblastoma cell lines, leukemia and lymphoma cell lines, phosphoinositide 3-kinase, proliferation, tumor inhibitors.

Abstract: The Phosphoinositide 3-kinase (PI3k) is an important regulator of intracellular signalling pathways, like cell proliferation, migration, survival, and angiogenesis upon activation by growth factor or receptors. The PI3k’s pathway is frequently up-regulated in human cancers, thus inhibition of PI3k’s is a promising approach for cancer therapy. Many potent PI3k’s inhibitors have been reported so far and few of them are in clinical trial like GDC-0941, BGT-226, AZD-6482 and others are natural products etc.

Cite this article as:

Joshi Chandra Mukesh, Kumar Krishan and Kumar Vikrant, Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology, Current Drug Discovery Technologies 2014; 11 (2) . https://dx.doi.org/10.2174/1570163810666131229130207