Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain

Title:Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain

Volume: 21 Issue: 18

Author(s): Y. Terasaki, Y. Liu, K. Hayakawa, L.D. Pham, E.H. Lo, X. Ji and K. Arai

Affiliation:

Keywords: Cell-cell interaction, extracellular vesicles, neuronal cell death, neuroprotection, neurovascular unit, stroke.

Abstract: The neurovascular unit is now well accepted as a conceptual framework for investigating the mechanisms of ischemic stroke. From a molecular and cellular perspective, three broad mechanisms may underlie stroke pathophysiology – excitotoxicity, oxidative stress and inflammation. To date, however, most investigations of these basic mechanisms have focused on neuronal responses. In this mini-review, we ask whether these mechanisms of excitotoxicity, oxidative stress and inflammation can also be examined in terms of non-neuronal interactions in the neurovascular unit, including the release of extracellular vesicles for cell-cell signaling.

Cite this article as:

Terasaki Y., Liu Y., Hayakawa K., Pham L.D., Lo E.H., Ji X. and Arai K., Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain, Current Medicinal Chemistry 2014; 21 (18) . https://dx.doi.org/10.2174/0929867321666131228223400