Calcium Ion – The Key Player in Cerebral Ischemia

Title:Calcium Ion – The Key Player in Cerebral Ischemia

Volume: 21 Issue: 18

Author(s): V.S. Suvanish Kumar, A. Gopalakrishnan, M. Naziroglu and G.K. Rajanikant

Affiliation:

Keywords: Ca²⁺ channels, Ca²⁺ ion, ischemia, neuronal damage, neuroprotection.

Abstract: Role of calcium ion (Ca²⁺) in the functioning of neurons from their naïve state to mature state is of vital importance. It controls functions such as neuronal functioning, neuronal ATP production, central nervous system migration and many others. Failure in Ca²⁺ homeostasis mechanisms and the resulting cellular Ca²⁺ ion load initiates a cascade of reactions involving various cytosolic enzymes and proteins. This total mechanism leads to the neuronal death. The ability of neurons to resist such death mechanisms fails as a result of extensive cell death signaling cascade reactions and later brings brain damage. The role of neuronal endoplasmic reticulum and protein channels like CaVs, TRP channels, and NMDAR as the mediators of cell damage and death has been evaluated in the studies related to cerebral ischemia. Here, we portray Ca²⁺ ion as one of the role players in neuronal death and cerebral damage following ischemia. The role of Ca²⁺ in neuronal functioning, its regulatory mechanisms and the failure of homeostatic mechanisms are discussed in detail.

Cite this article as:

Kumar Suvanish V.S., Gopalakrishnan A., Naziroglu M. and Rajanikant G.K., Calcium Ion – The Key Player in Cerebral Ischemia, Current Medicinal Chemistry 2014; 21 (18) . https://dx.doi.org/10.2174/0929867321666131228204246