Abstract
Secosteroids are an important group of modified steroids, which exhibits a variety of different biological activities. Studies on secosteroids have shown that modifications of the rigid tetracyclic steroidal carbon skeleton by cleavage of the internal C-C bonds provides more flexible compounds with new biological properties. The search for steroid compounds analogs with improved biological properties includes ring transformation into seco system. The recent development in the partial syntheses of secosteroids is described herein, as well as studies of methods for modifications of such molecules.
Keywords: Secosteroids, partial synthesis, reactivity, modification.
Current Organic Chemistry
Title:An Overview of Partial Synthesis and Transformations of Secosteroids
Volume: 18 Issue: 2
Author(s): Katarina Penov Gasi, Marija Sakac, Suzana Jovanovic-Santa and Evgenija Djurendic
Affiliation:
Keywords: Secosteroids, partial synthesis, reactivity, modification.
Abstract: Secosteroids are an important group of modified steroids, which exhibits a variety of different biological activities. Studies on secosteroids have shown that modifications of the rigid tetracyclic steroidal carbon skeleton by cleavage of the internal C-C bonds provides more flexible compounds with new biological properties. The search for steroid compounds analogs with improved biological properties includes ring transformation into seco system. The recent development in the partial syntheses of secosteroids is described herein, as well as studies of methods for modifications of such molecules.
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Cite this article as:
Gasi Penov Katarina, Sakac Marija, Jovanovic-Santa Suzana and Djurendic Evgenija, An Overview of Partial Synthesis and Transformations of Secosteroids, Current Organic Chemistry 2014; 18 (2) . https://dx.doi.org/10.2174/13852728113176660147
DOI https://dx.doi.org/10.2174/13852728113176660147 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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