Abstract
A set of new polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds, including 2- benzylbenzofuran-3(2H)-ones and 2-benzylbenzofurans, were designed and synthesized. Their antiproliferative activities were evaluated against human gastric cancer (SGC-7901), human fibrosarcoma (HT-1080) and human oral epidermoid carcinoma (KB) cell lines in vitro. Preliminary results showed that some polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds had significant activity comparable with that of cisplatin.
Keywords: Antiproliferative activity, Synthesis, Aurone, 2-Benzyl-2, 3-dihydrobenzofuran, 2-Benzylbenzofuran-3(2H)-ones, 2-Benzylbenzofurans.
32