Abstract
Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood. The work of many investigators has provided insights into many aspects of the autoregulatory mechanism, but many critical components remain elusive. This review is intended to update the reader on the role of P2 purinoceptors as a postulated mechanism responsible for renal autoregulatory resistance adjustments. It will summarize recent advances in normal function and it will touch on more recent ideas regarding autoregulatory insufficiency in hypertension and inflammation. Current thoughts on the nature of the mechanosensor responsible for myogenic behavior will be also be discussed as well as current thoughts on the mechanisms involved in ATP release to the extracellular fluid space.
Keywords: ATP, adenosine, afferent arterioles, P2 receptors, connexins, myogenic behavior, tubuloglomerular feedback.
Current Vascular Pharmacology
Title:P2 Receptors in Renal Autoregulation
Volume: 12 Issue: 6
Author(s): Zhengrong Guan, Robert C. Fellner, Justin Van Beusecum and Edward W. Inscho
Affiliation:
Keywords: ATP, adenosine, afferent arterioles, P2 receptors, connexins, myogenic behavior, tubuloglomerular feedback.
Abstract: Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood. The work of many investigators has provided insights into many aspects of the autoregulatory mechanism, but many critical components remain elusive. This review is intended to update the reader on the role of P2 purinoceptors as a postulated mechanism responsible for renal autoregulatory resistance adjustments. It will summarize recent advances in normal function and it will touch on more recent ideas regarding autoregulatory insufficiency in hypertension and inflammation. Current thoughts on the nature of the mechanosensor responsible for myogenic behavior will be also be discussed as well as current thoughts on the mechanisms involved in ATP release to the extracellular fluid space.
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Cite this article as:
Guan Zhengrong, Fellner C. Robert, Beusecum Van Justin and Inscho W. Edward, P2 Receptors in Renal Autoregulation, Current Vascular Pharmacology 2014; 12 (6) . https://dx.doi.org/10.2174/15701611113116660152
DOI https://dx.doi.org/10.2174/15701611113116660152 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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