Molecular Imaging of σ₁ Receptors In Vivo: Current Status and Perspectives

Title:Molecular Imaging of σ₁ Receptors In Vivo: Current Status and Perspectives

Volume: 21 Issue: 1

Author(s): P. Brust, W. Deuther-Conrad, K. Lehmkuhl, H. Jia and B. Wünsch

Affiliation:

Keywords: Brain, chaperone, cancer, disease, fluspidine, molecular imaging, positron emission tomography, sigma receptor, signalling, single photon emission computed tomography, therapy.

Abstract: It is widely accepted that sigma ( σ) receptors represent a new and different avenue in the possible pharmacological treatment of cancer and several brain-related disorders. Of the two different σ receptor types the σ₁ receptors are assumed to be of major impact for brain diseases. Molecular imaging of brain σ₁ receptors with positron emission tomography (PET) or single photon emission computed tomography (SPECT) may provide a significant contribution to the understanding of the cross-talk between σ₁ receptors and inter- and intracellular signalling systems. New insights into these functional interrelationships will allow a better diagnosis of brain and cancerous diseases and direct a rational development of new therapeutic concepts.

Cite this article as:

Brust P., Deuther-Conrad W., Lehmkuhl K., Jia H. and Wünsch B., Molecular Imaging of σ₁ Receptors In Vivo: Current Status and Perspectives, Current Medicinal Chemistry 2014; 21 (1) . https://dx.doi.org/10.2174/09298673113209990214