Abstract
Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship (SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring had significant impacts on the antiviral activity of quassinoids.
Keywords: Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.
Current Bioactive Compounds
Title:Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus
Volume: 9 Issue: 3
Author(s): Zheng-Kun Zhang, Ming-An Ouyang, Jia-Sui Zhan and Zu-Jian Wu
Affiliation:
Keywords: Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.
Abstract: Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship (SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring had significant impacts on the antiviral activity of quassinoids.
Export Options
About this article
Cite this article as:
Zhang Zheng-Kun, Ouyang Ming-An, Zhan Jia-Sui and Wu Zu-Jian, Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus, Current Bioactive Compounds 2013; 9 (3) . https://dx.doi.org/10.2174/15734072113099990013
DOI https://dx.doi.org/10.2174/15734072113099990013 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Evaluation of Non-Coding RNAs as Potential Targets in Head and Neck Squamous Cell Carcinoma Cancer Stem Cells
Current Drug Targets Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders
Current Pharmaceutical Design Microenvironment and Brain Tumor Stem Cell Maintenance: Impact of the Niche
Anti-Cancer Agents in Medicinal Chemistry Hematopoietic Stem Cells: Transcriptional Regulation, Ex Vivo Expansion and Clinical Application
Current Molecular Medicine Targeting DNA Minor Groove by Hybrid Molecules as Anticancer Agents
Current Medicinal Chemistry Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part I: Xanthones, Quinones, Steroids, Coumarins, Phenolics and other Classes of Compounds
Anti-Cancer Agents in Medicinal Chemistry Diterpenoids from Liverworts and their Biological Activities
Current Organic Chemistry Characteristics of Brain Tumor Stem Cells and the Rationale for Applying Tyrosine Kinase Inhibitors as Potential Targeting Agents
Recent Patents on Regenerative Medicine The Influence of Cox-2 and Bioactive Lipids on Hematological Cancers
Current Angiogenesis (Discontinued) The Role and Therapeutic Potential of Ser/Thr Phosphatase PP2A in Apoptotic Signalling Networks in Human Cancer Cells
Current Molecular Medicine Chemical Genomic and Proteomic Methods for Determining Kinase Inhibitor Selectivity
Combinatorial Chemistry & High Throughput Screening Modulation of Huntington’s Disease in Drosophila
CNS & Neurological Disorders - Drug Targets Toxicogenomics to Evaluate Endocrine Disrupting Effects of Environmental Chemicals Using the Zebrafish Model
Current Genomics Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review
Anti-Cancer Agents in Medicinal Chemistry Cyclin-Dependent Kinase Inhibition by Flavoalkaloids
Mini-Reviews in Medicinal Chemistry p73 as a Pharmaceutical Target for Cancer Therapy
Current Pharmaceutical Design Clear Cell Renal Cell Cancer Tumor-Propagating Cells: Molecular Characteristics
Current Signal Transduction Therapy Epigenetic Regulation and Therapeutic Approaches in Cancer
Current Topics in Medicinal Chemistry The Need for Calcium Channels in Cell Proliferation
Recent Patents on Anti-Cancer Drug Discovery Secondary Metabolites from Cordyceps Species and Their Antitumor Activity Studies
Recent Patents on Biotechnology