Abstract
In recent decades, growth of computing power has facilitated powerful techniques for reconstructing evolutionary relationships from online genetic and proteomic databases. These methods are useful tools for pharmacologists for analyzing relationships between receptors and associated enzymes. Phylogenetic analysis can help generate hypotheses and leads for experimentation. Reconstruction of molecular phylogenies for the nonspecialist is described in this article using the example of the orphaned g protein coupled receptor GPR18.
Keywords: Amino acid sequence, drug discovery, evolutionary biology, molecular phylogenetics, nucleotide sequence.
Current Drug Discovery Technologies
Title:Phylogenetic Methods in Drug Discovery
Volume: 10 Issue: 4
Author(s): John C. Ashton
Affiliation:
Keywords: Amino acid sequence, drug discovery, evolutionary biology, molecular phylogenetics, nucleotide sequence.
Abstract: In recent decades, growth of computing power has facilitated powerful techniques for reconstructing evolutionary relationships from online genetic and proteomic databases. These methods are useful tools for pharmacologists for analyzing relationships between receptors and associated enzymes. Phylogenetic analysis can help generate hypotheses and leads for experimentation. Reconstruction of molecular phylogenies for the nonspecialist is described in this article using the example of the orphaned g protein coupled receptor GPR18.
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Cite this article as:
Ashton C. John, Phylogenetic Methods in Drug Discovery, Current Drug Discovery Technologies 2013; 10 (4) . https://dx.doi.org/10.2174/15701638113109990033
DOI https://dx.doi.org/10.2174/15701638113109990033 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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