Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

Title:Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

Volume: 20 Issue: 16

Author(s): Sanela Smajilovic, Petrine Wellendorph and Hans Brauner-Osborne

Affiliation:

Keywords: Amino acid-sensing, 7TM receptors, CaSR, GPRC6A, T1R1/T1R3.

Abstract: A number of nutrient sensing seven trans-membrane (7TM) receptors have been identified and characterized over the past few years. While the sensing mechanisms to carbohydrates and free fatty acids are well understood, the molecular basis of amino acid sensing has recently come to the limelight. The present review describes the current status of promiscuous L-α-amino acid sensors, the calcium sensing receptor (CaSR), the GPRC6A receptor, the T1R1/T1R3 receptor and also their molecular pharmacology, expression pattern and physiological significance.

Cite this article as:

Smajilovic Sanela, Wellendorph Petrine and Brauner-Osborne Hans, Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids, Current Pharmaceutical Design 2014; 20 (16) . https://dx.doi.org/10.2174/13816128113199990576