Abstract
Neurons and neuroendocrine cells store nucleotides in vesicles and release them upon stimulation, leading to intercellular purinergic signaling. The molecular machinery responsible for the vesicular storage of nucleotides was a long standing enigma, however, recently the transporter involving in the process was identified. This article summarizes the history of vesicular storage of nucleotides and the identification of the vesicular nucleotide transporter (VNUT) responsible for the process. The significance of VNUT as a drug target to control purinergic chemical transmission is also discussed.
Keywords: Vesicular nucleotide transporter, secretory granules, synaptic vesicles, ATP, ADP, purinergic chemical transmission, drug target.
Current Pharmaceutical Design
Title:Vesicular Nucleotide Transport: A Brief History and the Vesicular Nucleotide Transporter as a Target for Drug Development
Volume: 20 Issue: 16
Author(s): Miki Hiasa, Natsuko Togawa and Yoshinori Moriyama
Affiliation:
Keywords: Vesicular nucleotide transporter, secretory granules, synaptic vesicles, ATP, ADP, purinergic chemical transmission, drug target.
Abstract: Neurons and neuroendocrine cells store nucleotides in vesicles and release them upon stimulation, leading to intercellular purinergic signaling. The molecular machinery responsible for the vesicular storage of nucleotides was a long standing enigma, however, recently the transporter involving in the process was identified. This article summarizes the history of vesicular storage of nucleotides and the identification of the vesicular nucleotide transporter (VNUT) responsible for the process. The significance of VNUT as a drug target to control purinergic chemical transmission is also discussed.
Export Options
About this article
Cite this article as:
Hiasa Miki, Togawa Natsuko and Moriyama Yoshinori, Vesicular Nucleotide Transport: A Brief History and the Vesicular Nucleotide Transporter as a Target for Drug Development, Current Pharmaceutical Design 2014; 20 (16) . https://dx.doi.org/10.2174/13816128113199990574
DOI https://dx.doi.org/10.2174/13816128113199990574 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Graphical Abstracts
Protein & Peptide Letters Stable Angina Pectoris: Current Medical Treatment
Current Pharmaceutical Design Cellular and Physiological Effects of Arginine
Mini-Reviews in Medicinal Chemistry Immune Responses to Fungal Infections and Therapeutic Implications
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Gastrointestinal Motility and Functional Gastrointestinal Diseases
Current Pharmaceutical Design Structure, Expression, and Regulation of UDP-GlcNAc: Dolichol Phosphate GlcNAc-1-Phosphate Transferase (DPAGT1)
Current Drug Targets Nanocarriers and their Actions to Improve Skin Permeability and Transdermal Drug Delivery
Current Pharmaceutical Design Statins: A Conceivable Remedial Role for the Regulation of Cancer Progression
Current Cancer Therapy Reviews Homocysteine-Lowering Treatment in Coronary Heart Disease
Current Medicinal Chemistry - Cardiovascular & Hematological Agents The PD-1/PD-L1 Pathway in Human Pathology
Current Molecular Medicine Stroke and Neuroinflamation: Role of Sexual Hormones
Current Pharmaceutical Design β-arrestin-Biased Agonism at the Parathyroid Hormone Receptor Uncouples Bone Formation from Bone Resorption
Endocrine, Metabolic & Immune Disorders - Drug Targets 5-HT and NA Reuptake Inhibitors and Appetite Regulation: The Role of the Central 5-HT Network
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Zinc, Metallothioneins and Longevity: Interrelationships with Niacin and Selenium
Current Pharmaceutical Design Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System
Current Stem Cell Research & Therapy Sirtuin Modulators: Targets for Metabolic Diseases and Beyond
Current Topics in Medicinal Chemistry Sirtuins: Possible Clinical Implications in Cardio and Cerebrovascular Diseases
Current Drug Targets Discrete Modelling of Powder Dispersion in Dry Powder Inhalers - A Brief Review
Current Pharmaceutical Design Stenting Renal Artery Stenosis: What is the Fuss All About?
Reviews on Recent Clinical Trials Implementation of a Biocircuit Implants for Neurotransmitter Release During Neuro-Stimulation
Current Neurovascular Research