Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

Title:Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

Volume: 13 Issue: 7

Author(s): Xin Tong and Jill C. Pelling

Affiliation:

Keywords: Akt, mTOR, apigenin, cancer.

Abstract: Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin’s inhibition of the PI3K/Akt/mTOR signaling pathways.

Cite this article as:

Tong Xin and Pelling C. Jill, Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (7) . https://dx.doi.org/10.2174/18715206113139990119