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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

A Dual Role for Sirtuin 1 in Tumorigenesis

Author(s): Yujiang Fang and Michael B. Nicholl

Volume 20, Issue 15, 2014

Page: [2634 - 2636] Pages: 3

DOI: 10.2174/13816128113199990488

Price: $65

Abstract

Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor. Its function in malignancy varies with concentration, cellular location, temporal and spatial distribution, and regulation by upstream and downstream factors. In this mini-review, we present the existing data which implicates SIRT1 in tumorigenesis.

Keywords: Sirtuin1, tumor.


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