Abstract
The development of locomotor function in terrestrial higher vertebrates takes place during both the embryonic period and the first days (or weeks, depending on the species) of postnatal life. It relies on the maturation of different elements such as musculoskeletal system, sensory systems, network connectivity, and neuronal intrinsic properties. This maturation results from the interplay between genetic determinants and activity dependent processes. Numerous studies have shown that aminergic (serotonin, noradrenaline, dopamine) projections to the spinal cord could contribute to the maturation of locomotor networks. In this review we will describe the development of aminergic projections in the spinal cord of higher terrestrial vertebrates, and we will review literature describing the trophic role played by these pathways on different parameters of locomotor function.
Keywords: Serotonin, noradrenaline, dopamine, locomotion, central pattern generator, neonatal development, embryonic development, mice, rats, chicken.
Current Pharmaceutical Design
Title:Role of Descending Aminergic Pathways in the Development of Locomotion
Volume: 19 Issue: 24
Author(s): Edouard Pearlstein
Affiliation:
Keywords: Serotonin, noradrenaline, dopamine, locomotion, central pattern generator, neonatal development, embryonic development, mice, rats, chicken.
Abstract: The development of locomotor function in terrestrial higher vertebrates takes place during both the embryonic period and the first days (or weeks, depending on the species) of postnatal life. It relies on the maturation of different elements such as musculoskeletal system, sensory systems, network connectivity, and neuronal intrinsic properties. This maturation results from the interplay between genetic determinants and activity dependent processes. Numerous studies have shown that aminergic (serotonin, noradrenaline, dopamine) projections to the spinal cord could contribute to the maturation of locomotor networks. In this review we will describe the development of aminergic projections in the spinal cord of higher terrestrial vertebrates, and we will review literature describing the trophic role played by these pathways on different parameters of locomotor function.
Export Options
About this article
Cite this article as:
Pearlstein Edouard, Role of Descending Aminergic Pathways in the Development of Locomotion, Current Pharmaceutical Design 2013; 19 (24) . https://dx.doi.org/10.2174/1381612811319240002
DOI https://dx.doi.org/10.2174/1381612811319240002 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Architectural Changes of Thigh Muscles in Patients with Subacute Stroke after Body Weight Support Treadmill Training
Current Medical Imaging End-Stage Dementia Spark of Life: Reliability and Validity of the “GATOS” Questionnaire
Current Alzheimer Research Modulation of Response to Audiovisual Stimuli Presented Peripherally by Visually Cued Endogenous Temporal Attention: An Event-Related Potentials Study
Neuroscience and Biomedical Engineering (Discontinued) Restless Legs Syndrome in Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets The Biology and Therapeutic Potential of the DDAH/ADMA Pathway
Current Pharmaceutical Design Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics
Current Medicinal Chemistry Protein Folding and Misfolding, Endoplasmic Reticulum Stress in Neurodegenerative Diseases: in Trace of Novel Drug Targets
Current Protein & Peptide Science Some Trends and Challenges in Nanomechanics: Up-To-Date Review of Selected Patents and Patent Applications
Recent Patents on Mechanical Engineering Parkinsons Disease: Genetics and Beyond
Current Neuropharmacology Neuroprotective Effects of Tetracyclines: Molecular Targets, Animal Models and Human Disease
CNS & Neurological Disorders - Drug Targets Critical Questions for Preclinical Trials on Safety and Efficacy of Vascular Endothelial Growth Factor-Based Therapeutic Angiogenesis for Ischemic Stroke
CNS & Neurological Disorders - Drug Targets Metabotropic Glutamate Receptor Genes as Candidates for Pharmacogenetic Studies of Current and Future Antipsychotic Agents in Schizophrenia
Current Pharmacogenomics Cancer Stem Cells in Hematological Disorders: Current and Possible New Therapeutic Approaches
Current Pharmaceutical Biotechnology Evaluation of the Superabsorbent Effect on the Yield and Some Growth Factors of Pisum sativum L. under Drought Stress Conditions
Recent Patents on Food, Nutrition & Agriculture Preface [Hot Topic: Cannabinoid Receptors (Guest Editor: Maria L. Lopez-Rodriguez)]
Current Medicinal Chemistry - Central Nervous System Agents New Agents and Approaches to Treatment in Niemann-Pick Type C Disease
Current Pharmaceutical Biotechnology Mechanisms of Action of Antipsychotic Drugs of Different Classes, Refractoriness to Therapeutic Effects of Classical Neuroleptics, and Individual Variation in Sensitivity to their Actions: PART I
Current Neuropharmacology New Perspectives in the Management of Post-Surgical Macular Edema
Recent Patents on Drug Delivery & Formulation Mitochondrial Calcium Signaling as a Therapeutic Target for Alzheimer’s Disease
Current Alzheimer Research Exploring the Role of Gene Therapy for Neurological Disorders
Current Gene Therapy