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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Role of Descending Aminergic Pathways in the Development of Locomotion

Author(s): Edouard Pearlstein

Volume 19, Issue 24, 2013

Page: [4332 - 4340] Pages: 9

DOI: 10.2174/1381612811319240002

Price: $65

Abstract

The development of locomotor function in terrestrial higher vertebrates takes place during both the embryonic period and the first days (or weeks, depending on the species) of postnatal life. It relies on the maturation of different elements such as musculoskeletal system, sensory systems, network connectivity, and neuronal intrinsic properties. This maturation results from the interplay between genetic determinants and activity dependent processes. Numerous studies have shown that aminergic (serotonin, noradrenaline, dopamine) projections to the spinal cord could contribute to the maturation of locomotor networks. In this review we will describe the development of aminergic projections in the spinal cord of higher terrestrial vertebrates, and we will review literature describing the trophic role played by these pathways on different parameters of locomotor function.

Keywords: Serotonin, noradrenaline, dopamine, locomotion, central pattern generator, neonatal development, embryonic development, mice, rats, chicken.


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