Abstract
La(NO3)3.6H2O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-friendliness, high atom economy, short times and the products were isolated with high yields.
Keywords: Lanthanum nitrate hexahydrate, piperidine, one-pot, multicomponent
Letters in Organic Chemistry
Title:La(NO3)3.6H2O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines
Volume: 10 Issue: 3
Author(s): Mir Rasul Mousavi, Jasem Aboonajmi, Malek Taher Maghsoodlou, Nourallah Hazeri, Sayyed Mostafa Habibi-Khorassani and Mohyeddin Safarzaei
Affiliation:
Keywords: Lanthanum nitrate hexahydrate, piperidine, one-pot, multicomponent
Abstract: La(NO3)3.6H2O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-friendliness, high atom economy, short times and the products were isolated with high yields.
Export Options
About this article
Cite this article as:
Rasul Mousavi Mir, Aboonajmi Jasem, Taher Maghsoodlou Malek, Hazeri Nourallah, Mostafa Habibi-Khorassani Sayyed and Safarzaei Mohyeddin, La(NO3)3.6H2O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines, Letters in Organic Chemistry 2013; 10 (3) . https://dx.doi.org/10.2174/1570178611310030005
DOI https://dx.doi.org/10.2174/1570178611310030005 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pathophysiological Roles of Renin-Angiotensin System on Erythropoietic Action
Current Hypertension Reviews Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs
Current Medicinal Chemistry Adipose-Derived Factors During Nutritional Transitions
Current Nutrition & Food Science Diabetes Mellitus: Novel Insights, Analysis and Interpretation of Pathophysiology and Complications Management with Imidazole-Containing Peptidomimetic Antioxidants
Recent Patents on Drug Delivery & Formulation Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research
Current Pharmaceutical Design Reactive Oxygen Species, Nitric Oxide and Hypertensive Endothelial Dysfunction
Current Hypertension Reviews Statin Treatment Non-adherence and Discontinuation: Clinical Implications and Potential Solutions
Current Pharmaceutical Design The Association Between HIV/AIDS During Pregnancy and Fetal Growth Parameters in Florida: A Population Based Study
Current HIV Research Minifish mtDNA has Abundance of Repeat Sequences and Inefficient Replication In Vitro
Current Molecular Medicine Diabetic Vasculopathy and the Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1)
Current Diabetes Reviews Sildenafil is Well Tolerated by Erectile Dysfunction Patients Taking Antihypertensive Medications, Including Those on Multidrug Regimens
Current Drug Safety Ethical and Policy Considerations in the Application of Pharmacogenomic Testing for Tardive Dyskinesia: Case Study of the Dopamine D3 Receptor
Current Pharmacogenomics and Personalized Medicine Effects of Amine Oxidases in Allergic and Histamine-Mediated Conditions
Recent Patents on Inflammation & Allergy Drug Discovery Neuromyelitis Optica (NMO IgG+) and Genetic Susceptibility, Potential Ethnic Influences
Central Nervous System Agents in Medicinal Chemistry Podocytes as Target of Vitamin D
Current Diabetes Reviews Tripeptide Amide L-pyroglutamyl-Histidyl-L-Prolineamide (L-PHPThyrotropin- Releasing Hormone, TRH) Promotes Insulin-Producing Cell Proliferation
Current Aging Science A Review of Intrahepatic Cholestasis of Pregnancy
Current Women`s Health Reviews Pleiotropic Effects of ARB in Metabolic Syndrome
Current Vascular Pharmacology Oxidative Stress and the JNK Pathway in Diabetes
Current Diabetes Reviews Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
Current Neuropharmacology