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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

La(NO3)3.6H2O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines

Author(s): Mir Rasul Mousavi, Jasem Aboonajmi, Malek Taher Maghsoodlou, Nourallah Hazeri, Sayyed Mostafa Habibi-Khorassani and Mohyeddin Safarzaei

Volume 10, Issue 3, 2013

Page: [171 - 177] Pages: 7

DOI: 10.2174/1570178611310030005

Price: $65

Abstract

La(NO3)3.6H2O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-friendliness, high atom economy, short times and the products were isolated with high yields.

Keywords: Lanthanum nitrate hexahydrate, piperidine, one-pot, multicomponent


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