Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents

Title:Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents

Volume: 10 Issue: 5

Author(s): Mehlika Dilek Altintop, Ahmet Ozdemir, Zafer Asim Kaplancikli, Gulhan Turan-Zitouni, Gokalp Iscan and Gulsen Akalin Ciftci

Affiliation:

Keywords: Amide, Benzothiazole, Piperidine, Antimicrobial activity, Cytotoxicity

Abstract: In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds were elucidated by ¹H-NMR and mass spectral data and elemental analysis. The compounds were screened for their antimicrobial activities against pathogenic bacteria and Candida species. The compounds were also investigated for their cytotoxic properties using MTT assay. The microbiological results revealed that the compounds were more effective against fungi than bacteria. Among Candida species, C. utilis was the most susceptible fungus to compounds 7 and 11. It is apparent that 2,6-dimethylpiperidine group and chloro and methyl substituents on benzothiazole ring have an important impact on anticandidal activity. MTT assay indicated that the effective doses of these derivatives were lower than their cytotoxic doses.

Cite this article as:

Dilek Altintop Mehlika, Ozdemir Ahmet, Asim Kaplancikli Zafer, Turan-Zitouni Gulhan, Iscan Gokalp and Akalin Ciftci Gulsen, Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents, Letters in Drug Design & Discovery 2013; 10 (5) . https://dx.doi.org/10.2174/1570180811310050013