Abstract
Since the initial evidence that antennapedia homeobox [1] can cross cell membranes and internalize into cells, numerous peptides with similar translocation properties have been described. These peptides are referred to as cell-penetrating peptides (CPPs) or protein- transduction domains (PTDs). Reviews on reported CPP sequences have been recently published [2,3], together with reviews on their mechanisms of internalization [2,4-6].
In this review, we will focus on natural homeoproteins and homeoprotein-derived peptides and describe results that have been obtained among different laboratories to unravel the different pathways by which these molecules reach the cell cytosol and nucleus or transfer from one cell to another. Using homeoproteins as a paradigm, we will also summarize recent evidences of the physiological functions of endogenous protein translocation.
Keywords: Homeodomain, homeoprotein, cell-penetrating peptide, membrane translocation, endocytosis, glycosaminoglycans, secretion
Current Pharmaceutical Design
Title:Homeoproteins and Homeoprotein-derived Peptides: Going in and Out
Volume: 19 Issue: 16
Author(s): Sandrine Sagan, Fabienne Burlina, Isabel D. Alves, Cherine Bechara, Edmond Dupont and Alain Joliot
Affiliation:
Keywords: Homeodomain, homeoprotein, cell-penetrating peptide, membrane translocation, endocytosis, glycosaminoglycans, secretion
Abstract: Since the initial evidence that antennapedia homeobox [1] can cross cell membranes and internalize into cells, numerous peptides with similar translocation properties have been described. These peptides are referred to as cell-penetrating peptides (CPPs) or protein- transduction domains (PTDs). Reviews on reported CPP sequences have been recently published [2,3], together with reviews on their mechanisms of internalization [2,4-6].
In this review, we will focus on natural homeoproteins and homeoprotein-derived peptides and describe results that have been obtained among different laboratories to unravel the different pathways by which these molecules reach the cell cytosol and nucleus or transfer from one cell to another. Using homeoproteins as a paradigm, we will also summarize recent evidences of the physiological functions of endogenous protein translocation.
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Cite this article as:
Sagan Sandrine, Burlina Fabienne, D. Alves Isabel, Bechara Cherine, Dupont Edmond and Joliot Alain, Homeoproteins and Homeoprotein-derived Peptides: Going in and Out, Current Pharmaceutical Design 2013; 19 (16) . https://dx.doi.org/10.2174/1381612811319160002
DOI https://dx.doi.org/10.2174/1381612811319160002 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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