Abstract
Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity
Current Drug Targets
Title:Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review
Volume: 14 Issue: 4
Author(s): Sinoy Sugunan, Diya Binoy Joseph and G. K. Rajanikant
Affiliation:
Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity
Abstract: Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
Export Options
About this article
Cite this article as:
Sugunan Sinoy, Binoy Joseph Diya and K. Rajanikant G., Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review, Current Drug Targets 2013; 14 (4) . https://dx.doi.org/10.2174/1389450111314040011
DOI https://dx.doi.org/10.2174/1389450111314040011 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Antioxidant Therapy for Prevention of Inflammation, Ischemic Reperfusion Injuries and Allograft Rejection
Cardiovascular & Hematological Agents in Medicinal Chemistry The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications
Current Medicinal Chemistry KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma
Current Neuropharmacology A3 Receptor Ligands: Past, Present and Future Trends
Current Topics in Medicinal Chemistry Involvement of Toll-like Receptors in Ischemia-induced Neuronal Damage
Central Nervous System Agents in Medicinal Chemistry Inodilators in the Management of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery
Current Vascular Pharmacology Phosphoinositide 3-Kinases and Leukocyte Migration
Current Immunology Reviews (Discontinued) Why and how do Microbubbles Enhance the Effectiveness of Diagnostic and Therapeutic Interventions in Cerebrovascular Disease?
Current Pharmaceutical Design Angiogenesis-regulating microRNAs and Ischemic Stroke
Current Vascular Pharmacology The Significance of Endothelium-Derived Hyperpolarizing Factor in the Human Circulation
Current Vascular Pharmacology The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications
Current Pharmaceutical Design State of the Heart: CMR in Coronary Artery Disease
Current Medical Imaging Pulmonary Arterial Hypertension in Connective Tissue Diseases
Current Respiratory Medicine Reviews Marrow Stromal Cells: Implications in Health and Disease in the Nervous System
Current Molecular Medicine Ethyl Pyruvate: A Novel Treatment for Sepsis
Current Drug Targets Oxidative Stress and Post-Stroke Depression: Possible Therapeutic Role of Polyphenols?
Current Medicinal Chemistry Therapeutic Potential of Plant Extracts and Phytochemicals Against Brain Ischemia-Reperfusion Injury: A Review
The Natural Products Journal Exploration of the Medicinal Peptide Space
Protein & Peptide Letters Modulation of Fatty Acids Oxidation in Heart Failure by Selective Pharmacological Inhibition of 3-Ketoacyl Coenzyme-A Thiolase
Current Clinical Pharmacology Pharmacology of the Human Saphenous Vein
Current Vascular Pharmacology