Abstract
Peroxisome Proliferator Activated Receptors gamma (PPARγ) are a class of ligand activated transcription factors with a prominent role in the regulation of metabolic processes. The present work aims towards examining the functional and structural features that facilitate the binding of small molecules based on Thiazolidinedione pharmacophore to PPARs. The intent of this article is to review all the reported thiazolidinediones and associated groups of PPARγ ligands.
Keywords: Natural ligands, Pharmacophore, PPARγ, Synthetic ligands, Thiazolidinediones, Type II Diabetes
Mini-Reviews in Medicinal Chemistry
Title:A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists
Volume: 13 Issue: 5
Author(s): Pooja S. Banerjee and Subir Samanta
Affiliation:
Keywords: Natural ligands, Pharmacophore, PPARγ, Synthetic ligands, Thiazolidinediones, Type II Diabetes
Abstract: Peroxisome Proliferator Activated Receptors gamma (PPARγ) are a class of ligand activated transcription factors with a prominent role in the regulation of metabolic processes. The present work aims towards examining the functional and structural features that facilitate the binding of small molecules based on Thiazolidinedione pharmacophore to PPARs. The intent of this article is to review all the reported thiazolidinediones and associated groups of PPARγ ligands.
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Cite this article as:
S. Banerjee Pooja and Samanta Subir, A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists, Mini-Reviews in Medicinal Chemistry 2013; 13 (5) . https://dx.doi.org/10.2174/1389557511313050007
DOI https://dx.doi.org/10.2174/1389557511313050007 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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