Recent Progress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines

Title:Recent Progress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines

Volume: 13 Issue: 4

Author(s): Aiping Huang and Chen Ma

Affiliation:

Keywords: 5-HT3 Receptor agonists, anticancer agents, anti-HIV agents, antimalarial agents, PARP-1 inhibitors, pyrroloquinoxalines, synthetic methodologies

Abstract: Pyrroloquinoxalines have proved to be a very attractive scaffold for medicinal chemist in the recent past. These compounds were extensively studied as bioactive compounds and many of them are known to be biologically and medicinally useful molecules, such as anti-HIV agents, antimalarial agents, antagonist agents, anticancer agents, and PARP-1 inhibitors. Additionally, pyrroloquinoxalines are also important intermediates for the construction of 5-HT3 receptor agonists. In this review the developments in biological activities and synthetic methodologies of pyrroloquinoxalines are discussed.

Cite this article as:

Huang Aiping and Ma Chen, Recent Progress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines, Mini-Reviews in Medicinal Chemistry 2013; 13 (4) . https://dx.doi.org/10.2174/1389557511313040012