Abstract
Novel pyrazoles, bipyrazoles and pyrazol-3-ylpyrazolo[3,4-d]pyrimidines were synthesized using the versatil synthon 2-(1Hbenzimidazol- 2-yl)-3,3-bis(methylthio) acrylonitrile (1). Reactions were carried out under silent and ultrasonic conditions. In general, improvement in rates and yields were observed when reactions were carried out under ultrasonic irradiation compared with silent condition. Structures of the products were established on analytical and spectral data.
Keywords: Pyrazoles, Bipyrazoles, Benzimidazole, Ultrasonic irradiation, Pyrazolo[3, 4-d]pyrimidine
Current Organic Chemistry
Title:An Efficiently Sonochemical Synthesis of Novel Pyrazoles, Bipyrazoles and Pyrazol-3- ylPyrazolo[3,4-d]pyrimidines Incorporating 1H-benzoimidazole Moiety
Volume: 17 Issue: 2
Author(s): Nesreen S. Ahmed, Tamer S. Saleh and El-Sayed H. El-Mossalamy
Affiliation:
Keywords: Pyrazoles, Bipyrazoles, Benzimidazole, Ultrasonic irradiation, Pyrazolo[3, 4-d]pyrimidine
Abstract: Novel pyrazoles, bipyrazoles and pyrazol-3-ylpyrazolo[3,4-d]pyrimidines were synthesized using the versatil synthon 2-(1Hbenzimidazol- 2-yl)-3,3-bis(methylthio) acrylonitrile (1). Reactions were carried out under silent and ultrasonic conditions. In general, improvement in rates and yields were observed when reactions were carried out under ultrasonic irradiation compared with silent condition. Structures of the products were established on analytical and spectral data.
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Cite this article as:
S. Ahmed Nesreen, S. Saleh Tamer and H. El-Mossalamy El-Sayed, An Efficiently Sonochemical Synthesis of Novel Pyrazoles, Bipyrazoles and Pyrazol-3- ylPyrazolo[3,4-d]pyrimidines Incorporating 1H-benzoimidazole Moiety, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020016
DOI https://dx.doi.org/10.2174/1385272811317020016 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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