Abstract
The aims of this research were to obtain improved wound dressings based on collagen (COLL), polysaccharides (dextran= DEX, diethylaminoethyl-cellulose= DEAEC), silica network and usnic acid, as quorum sensing inhibitor. FT-IR, SEM, interaction with eukaryotic cells and a novel protocol to evaluate the antimicrobial activity of the new wound dressing, firstly reported in literature were used for the characterization of fabricated wound dressings. The obtained wound dressings are not cytotoxic, do not influences the mesenchymal stem and exhibit good anti-biofilm properties. Taken together, these results are suggesting that the new systems can be safely used for local applications on the lesional tissues.
Keywords: Collagen biomaterial, Wound dressing, Usnic acid, Anti-biofilm
Current Organic Chemistry
Title:Wound Dressing Based Collagen Biomaterials Containing Usnic Acid as Quorum Sensing Inhibitor Agent: Synthesis, Characterization and Bioevaluation
Volume: 17 Issue: 2
Author(s): Alexandru Mihai Grumezescu, Ecaterina Andronescu, Madalina Georgiana Albu, Anton Ficai, Coralia Bleotu, Denisa Dragu and Veronica Lazar
Affiliation:
Keywords: Collagen biomaterial, Wound dressing, Usnic acid, Anti-biofilm
Abstract: The aims of this research were to obtain improved wound dressings based on collagen (COLL), polysaccharides (dextran= DEX, diethylaminoethyl-cellulose= DEAEC), silica network and usnic acid, as quorum sensing inhibitor. FT-IR, SEM, interaction with eukaryotic cells and a novel protocol to evaluate the antimicrobial activity of the new wound dressing, firstly reported in literature were used for the characterization of fabricated wound dressings. The obtained wound dressings are not cytotoxic, do not influences the mesenchymal stem and exhibit good anti-biofilm properties. Taken together, these results are suggesting that the new systems can be safely used for local applications on the lesional tissues.
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Mihai Grumezescu Alexandru, Andronescu Ecaterina, Georgiana Albu Madalina, Ficai Anton, Bleotu Coralia, Dragu Denisa and Lazar Veronica, Wound Dressing Based Collagen Biomaterials Containing Usnic Acid as Quorum Sensing Inhibitor Agent: Synthesis, Characterization and Bioevaluation, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020007
DOI https://dx.doi.org/10.2174/1385272811317020007 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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