Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A2

Title:Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A2

Volume: 12 Issue: 21

Author(s): E.L. Schaeffer, W.F. Gattaz and G.P. Eckert

Affiliation:

Keywords: schizophrenia, neuroimaging, membrane, phospholipase A2, dopamine

Abstract: Physiological enzymatic cleavage of membrane phospholipids by phospholipase A2 (PLA2) results in normal levels of phosphomonoester and phosphodiester, by which a normal dopamine neurotransmission is maintained. Data from postmortem tissue and in vivo imaging studies suggest that increased activity of intracellular calcium-independent PLA2 (iPLA2) in the brain of schizophrenic patients might accelerate the breakdown of membrane phospholipids and alter the properties of neuronal membranes, which in turn contributes to a hypodopaminergy. Alterations in PLA2 activity are probably genetically determined and represent a possible pharmacological target for Schizophrenia.

Cite this article as:

Schaeffer E.L., Gattaz W.F. and Eckert G.P., Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A2, Current Topics in Medicinal Chemistry 2012; 12 (21) . https://dx.doi.org/10.2174/1568026611212210004