Novel 2-(2-Benzylidenehydrazinyl)Benzo[d]Thiazole as Potential Antitubercular Agents

Title:Novel 2-(2-Benzylidenehydrazinyl)Benzo[d]Thiazole as Potential Antitubercular Agents

Volume: 16 Issue: 3

Author(s): Vinod Kumar Bairwa and Vikas N. Telvekar

Affiliation:

Keywords: (Aryloxy) benzaldehyde, anti-TB, benzothiazole, hybridization approach

Abstract: Molecular hybridization approach was used to synthesize substituted 2-(2-(4-aryl oxy benzylidene) hydrazinyl)benzo thiazole derivatives with 2-hydrazinobenzothiazole and 4-(alicycli/aryl/biaryl/heteroaryl oxy)benzaldehyde as new anti-TB agents. The synthesized compounds, when tested against H37Rv strains of Mtb using Resazurin Microtitre Assay (REMA) method, showed promising activity (MIC 1.35-36.50μg/mL). 6-chloro-2-(2-(4- (pyridin-4-yloxy) benzylidene) hydrazinyl) benzo[d]thiazole (10v) gave MIC of 1.35 μg/mL. Thus making it, a potential lead could be developed for further antitubercular studies.

Cite this article as:

Kumar Bairwa Vinod and N. Telvekar Vikas, Novel 2-(2-Benzylidenehydrazinyl)Benzo[d]Thiazole as Potential Antitubercular Agents, Combinatorial Chemistry & High Throughput Screening 2013; 16 (3) . https://dx.doi.org/10.2174/1386207311316030009