Abstract
The endoplasmic reticulum has a central role in biosynthesis of a variety of proteins and lipids. Mitochondria generate ATP, synthesize and process numerous metabolites, and are key regulators of cell death. The architectures of endoplasmic reticulum and mitochondria change continually via the process of membrane fusion, fission, elongation, degradation, and renewal. These structural changes correlate with important changes in organellar function. Both organelles are capable of moving along the cytoskeleton, thus changing their cellular distribution. Numerous studies have demonstrated coordination and communication between mitochondria and endoplasmic reticulum. A focal point for these interactions is a zone of close contact between them known as the mitochondrial–associated endoplasmic reticulum membrane (MAM), which serves as a signaling juncture that facilitates calcium and lipid transfer between organelles. Here we review the emerging data on how communication between endoplasmic reticulum and mitochondria can modulate organelle function and determine cellular fate.
Keywords: Cell death, endoplasmic reticulum, metabolism, mitochondria.
Current Molecular Medicine
Title:Cell Death and Survival Through the Endoplasmic Reticulum- Mitochondrial Axis
Volume: 13 Issue: 2
Author(s): R. Bravo-Sagua, A. E. Rodriguez, J. Kuzmicic, T. Gutierrez, C. Lopez-Crisosto, C. Quiroga, J. Diaz-Elizondo, M. Chiong, T. G. Gillette, B. A. Rothermel and S. Lavandero
Affiliation:
Keywords: Cell death, endoplasmic reticulum, metabolism, mitochondria.
Abstract: The endoplasmic reticulum has a central role in biosynthesis of a variety of proteins and lipids. Mitochondria generate ATP, synthesize and process numerous metabolites, and are key regulators of cell death. The architectures of endoplasmic reticulum and mitochondria change continually via the process of membrane fusion, fission, elongation, degradation, and renewal. These structural changes correlate with important changes in organellar function. Both organelles are capable of moving along the cytoskeleton, thus changing their cellular distribution. Numerous studies have demonstrated coordination and communication between mitochondria and endoplasmic reticulum. A focal point for these interactions is a zone of close contact between them known as the mitochondrial–associated endoplasmic reticulum membrane (MAM), which serves as a signaling juncture that facilitates calcium and lipid transfer between organelles. Here we review the emerging data on how communication between endoplasmic reticulum and mitochondria can modulate organelle function and determine cellular fate.
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Bravo-Sagua R., Rodriguez E. A., Kuzmicic J., Gutierrez T., Lopez-Crisosto C., Quiroga C., Diaz-Elizondo J., Chiong M., Gillette G. T., Rothermel A. B. and Lavandero S., Cell Death and Survival Through the Endoplasmic Reticulum- Mitochondrial Axis, Current Molecular Medicine 2013; 13 (2) . https://dx.doi.org/10.2174/1566524011313020008
DOI https://dx.doi.org/10.2174/1566524011313020008 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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