Synthesis and In-vitro Photodynamic Studies of the Superparamagnetic Chitosan Hydrogel/Chlorin E6 Nanocarriers

Title:Synthesis and In-vitro Photodynamic Studies of the Superparamagnetic Chitosan Hydrogel/Chlorin E6 Nanocarriers

Volume: 9 Issue: 1

Author(s): Mohammad Reza Saboktakin, Roya M. Tabatabaie, Fahimeh Satarzade Amini, Abel Maharramov and Mohammad Ali Ramazanov

Affiliation:

Keywords: Photodynamic therapy, Nanocarriers, Chlorine E6, intelligent carrier, Hydrogel

Abstract: The objective of the present study was to develop superparamagnetic chitosan(CS) – dextran sulfate(DS) hydrogels as a intelligent drug system for effective carrying of Chlorin E6(chn E6) photosensitizer to cancer cells. This system can be detectable by magnetic Resonance Imaging technique. The study shows that the lifetime of the triplet state for chn E6 photosensitizer is significantly increase when encapsulate into hydrogel. In addition to the possible enhancement of 1O2 generation, other advantages to incorporating chn E6 -based PS agents into hydrogel include the ability to solubilize these generally hydrophobic agents, the small and uniform size of hydrogels, and potential for passive targeting of solid tumors via the enhanced permeation and retention effect decreasing systemic photosensitization.

Cite this article as:

Reza Saboktakin Mohammad, M. Tabatabaie Roya, Satarzade Amini Fahimeh, Maharramov Abel and Ali Ramazanov Mohammad, Synthesis and In-vitro Photodynamic Studies of the Superparamagnetic Chitosan Hydrogel/Chlorin E6 Nanocarriers, Medicinal Chemistry 2013; 9 (1) . https://dx.doi.org/10.2174/1573406411309010112