Novel C-9, 9'-O-acyl Esters of (-)-Carinol as Free-radical Scavengers and Xanthine Oxidase Enzyme Inhibitors: Synthesis and Biological Evaluation

Title:Novel C-9, 9'-O-acyl Esters of (-)-Carinol as Free-radical Scavengers and Xanthine Oxidase Enzyme Inhibitors: Synthesis and Biological Evaluation

Volume: 9 Issue: 1

Author(s): Praveen Kumar Suryadevara, Hari Babu Tatipaka, Rama Subba Rao Vidadala, Ashok k Tiwari, Janaswamy Madhusudana Rao and Katragadda Suresh Babu

Affiliation:

Keywords: (-)-Carinol, Acyl derivatives, Xanthine oxidase inhibition, Free radical scavenging activity

Abstract: New compounds with hydrophyllic esters of (-)-carinol were synthesized and evaluated as xanthine oxidase enzyme inhibitors and antioxidants. Aliphatic esterfication of C-9,9'-OH groups of (-)-carinol resulted in lowering antioxidant and xanthine oxidase inhibitory activities. However certain aromatic acyl esters considerably improved the xathine oxidase inhibition. Aromatic esterification with electron withdrawing substitutions would preferred for improvement in XOD inhibition while retaining radical scavenging activity, electron withdrawing substitution led to the loss of free radical scavenging property and neutral substituents decrease the enzyme inhibitory potential.

Cite this article as:

Kumar Suryadevara Praveen, Babu Tatipaka Hari, Subba Rao Vidadala Rama, k Tiwari Ashok, Madhusudana Rao Janaswamy and Suresh Babu Katragadda, Novel C-9, 9'-O-acyl Esters of (-)-Carinol as Free-radical Scavengers and Xanthine Oxidase Enzyme Inhibitors: Synthesis and Biological Evaluation, Medicinal Chemistry 2013; 9 (1) . https://dx.doi.org/10.2174/1573406411309010100