Is Helicobacter pylori the Infectious Target to Prevent Gastric Cancer? An Interdisciplinary Point of View

Carmelo      Luigiano; Francesco      Ferrara; Sharmila      Fagoonee; Carlo      Fabbri; Vincenzo      Cennamo; Clara      Virgilio; Marco      Bassi; Carmelo      Favara; Carmela      Morace; Pierluigi      Consolo; Rinaldo      Pellicano

doi:10.2174/187152612804142206

Abstract

Gastric carcinogenesis, which may well extend over decades, is characterized by a slow stepwise evolution from superficial gastritis to glandular atrophy, intestinal metaplasia, dysplasia, and finally, adenocarcinoma. This sequence provides an excellent opportunity for the prevention or early detection of the events preceding development of the neoplasm. In 1994, the International Agency for Research on Cancer defined Helicobacter pylori (H. pylori) as a group I carcinogen for gastric cancer (GC). Evidence supporting a causal association has been demonstrated by epidemiological data as well as by experimental animal models. A meta-analysis has shown an higher risk (odds ratio: 1.92) of progression to GC in infected compare to uninfected subjects, that increased to a value >8 considering the surveys having a follow-up of more than 8 years. A crucial question remains whether and when precancerous lesions can reverse after H. pylori eradication. While several prospective studies have cast doubts about this reversibility others obtained opposing results. Currently, H. pylori is recognized as a necessary but insufficient cause of GC. The most accepted model of gastric carcinogenesis provides, like for other cancers, a multifactorial pathogenesis, linked with a number of initiators and other continuator agents. This review presents a multidisciplinary point of view to approaching the relationship between H. pylori infection and GC, focusing on the potential benefits of bacterial eradication in slowing down or in inducing regression of precancerous lesions.

Keywords: Helicobacter pylori, gastric cancer, intestinal metaplasia, Gastric carcinogenesis, glandular atrophy, dysplasia, adenocarcinoma, precancerous lesions, multifactorial pathogenesis, bacterial eradication, neoplasms, biotechnologies, gastroduodenal diseases, gastric MALT lymphoma