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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH

Author(s): Ling-ling Zhao, Yu Wan, Hai-ying Wang, Chao Wang, Xiao-xiao Zhang, Shu-ying Huang, Gui-xiang Liu, Liang-feng Chen and Hui Wu

Volume 9, Issue 9, 2012

Page: [671 - 676] Pages: 6

DOI: 10.2174/157017812803521144

Price: $65

Abstract

Chain 1,3-dicarbonyl compounds were firstly used as starting material to react with 5-amino-3-methyl-1- phenylpyrazol and aromatic aldehydes to prepare 1H-pyrazolo[3,4-b]pyridines in basic ionic liquid [bmim]OH. The onestep three-component reaction is simple and efficient. Additionally, water was the only one by-product during the whole process.

Keywords: Basic ionic liquid, pyrazolo[3, 4-b]pyridines, infertility, addiction, symptoms, inhibitors, three-component reaction, pKa, steric hindrance, recrystallized


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