Novel Piperazinyl Derivatives with Anti-Hyperalgesic, Anti-Allodynic and Anti-Inflammatory activities Useful for the Treatment of Neuropathic Pain

Title:Novel Piperazinyl Derivatives with Anti-Hyperalgesic, Anti-Allodynic and Anti-Inflammatory activities Useful for the Treatment of Neuropathic Pain

Volume: 11 Issue: 2

Author(s): Monika Sharma, Shraddha Suman Dash, Gangadhar Matharasala, Vanamala Deekshith, Dharmarajan Sriram and Perumal Yogeeswari

Affiliation:

Keywords: Neuropathic pain, antiallodynic, antihyperalgesic, carrageenan, nitric oxide, DPPH

Abstract: A series of structurally novel compounds possessing 2-phenylpiperazin-1-yl nicotinamide template was synthesized and evaluated for neuropathic pain activity. After the assessment of neurotoxicity and peripheral analgesic activity, the compounds were evaluated in a peripheral neuropathic pain model, the chronic constriction injury (CCI) to assess their antiallodynic and antihyperalgesic potential. Studies carried out to assess the underlying mechanism revealed that the compounds (5 and 6) suppressed the inflammatory component of the neuropathic pain and inhibited oxidative and nitrosative stress.

Cite this article as:

Sharma Monika, Suman Dash Shraddha, Matharasala Gangadhar, Deekshith Vanamala, Sriram Dharmarajan and Yogeeswari Perumal, Novel Piperazinyl Derivatives with Anti-Hyperalgesic, Anti-Allodynic and Anti-Inflammatory activities Useful for the Treatment of Neuropathic Pain, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2012; 11 (2) . https://dx.doi.org/10.2174/187152312803305704