Abstract
We proposed a method of synthesis to produce [11C]Choline using TRACERlab FXc module that utilized gas phase iodination. The product had radiochemical purity of 99.79 + 0.14 % and specific activity of 45.7 + 7.59 GBq/mol. [11C]Choline did not have at the moment a specific monograph in European Pharmacopeia therefore we used, when possible, as quality controls reference the monograph of [18F]FDG and we proposed suitable methods to verify radiochemical purity and to quantify residual DMAE and choline amounts.
Keywords: [11C]CH3I, [11C]Choline, gas phase iodination, prostate cancer, PET, quality controls, radiopharmaceutical, TRACERlab FXc
Medicinal Chemistry
Title:Description of High Purity and High Specific Activity of [11C]Choline Synthesis Using TRACERlab FXc Module, and Detailed Report of Quality Controls
Volume: 8 Issue: 6
Author(s): Giorgio Biasiotto, Francesco Bertagna, Ugo Biasiotto, Carlo Rodella, Giovanni Bosio, Luigi Caimi, Giovanni Bettinsoli and Raffaele Giubbini
Affiliation:
Keywords: [11C]CH3I, [11C]Choline, gas phase iodination, prostate cancer, PET, quality controls, radiopharmaceutical, TRACERlab FXc
Abstract: We proposed a method of synthesis to produce [11C]Choline using TRACERlab FXc module that utilized gas phase iodination. The product had radiochemical purity of 99.79 + 0.14 % and specific activity of 45.7 + 7.59 GBq/mol. [11C]Choline did not have at the moment a specific monograph in European Pharmacopeia therefore we used, when possible, as quality controls reference the monograph of [18F]FDG and we proposed suitable methods to verify radiochemical purity and to quantify residual DMAE and choline amounts.
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Biasiotto Giorgio, Bertagna Francesco, Biasiotto Ugo, Rodella Carlo, Bosio Giovanni, Caimi Luigi, Bettinsoli Giovanni and Giubbini Raffaele, Description of High Purity and High Specific Activity of [11C]Choline Synthesis Using TRACERlab FXc Module, and Detailed Report of Quality Controls, Medicinal Chemistry 2012; 8 (6) . https://dx.doi.org/10.2174/1573406411208061182
DOI https://dx.doi.org/10.2174/1573406411208061182 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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