Abstract
Apoptosis is a rare event in normal hepatocytes. However, multiple signals can trigger apoptosis in hepatocytes and it plays a role in the pathogenesis of many liver diseases. This review summarizes the mechanisms of hepatocellular apoptosis and the importance of apoptosis in the pathological processes of liver disease. The potential for non-invasive biomarkers of apoptosis to gauge the extent and follow the evolution of clinical disease is emphasized.
Keywords: Cytokeratin 18, Fas antigen, Fas ligand, Tumour necrosis factor, soluble trail, Biomarkers, Apoptosis, liver diseases, non-invasive biomarkers
Current Pharmaceutical Biotechnology
Title:Biomarkers for Hepatocellular Apoptosis in the Management of Liver Diseases
Volume: 13 Issue: 11
Author(s): Marie V. St-Pierre and Jean-Francois Dufour
Affiliation:
Keywords: Cytokeratin 18, Fas antigen, Fas ligand, Tumour necrosis factor, soluble trail, Biomarkers, Apoptosis, liver diseases, non-invasive biomarkers
Abstract: Apoptosis is a rare event in normal hepatocytes. However, multiple signals can trigger apoptosis in hepatocytes and it plays a role in the pathogenesis of many liver diseases. This review summarizes the mechanisms of hepatocellular apoptosis and the importance of apoptosis in the pathological processes of liver disease. The potential for non-invasive biomarkers of apoptosis to gauge the extent and follow the evolution of clinical disease is emphasized.
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Cite this article as:
V. St-Pierre Marie and Dufour Jean-Francois, Biomarkers for Hepatocellular Apoptosis in the Management of Liver Diseases, Current Pharmaceutical Biotechnology 2012; 13 (11) . https://dx.doi.org/10.2174/138920112802502097
DOI https://dx.doi.org/10.2174/138920112802502097 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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