Perspectives of New Therapies for Endometriosis

Jenny      V. Garmendia; Juan      B. De Sanctis

doi:10.2174/187221412802481702

Abstract

Endometriosis is an inflammatory disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease affects: ovarian function, oocyte quality, embryo development and implantation, and uterine function resulting in infertility or spontaneous pregnancy loss. Even though the world’s prevalence is above 10 %, an effective treatment has not yet been found. New pharmacological approaches have been designed and patented that could serve as future therapies for this disease.

Keywords: Androgens, coagulation, endometriosis, fertility, GnHR, inflammation, progesterone, signal transduction.