A Novel and Facile Synthetic Approach for Tasigna

Title:A Novel and Facile Synthetic Approach for Tasigna

Volume: 8 Issue: 5

Author(s): Xiaoyan Pan, Wen Lu, Pengfei Li, Fang Wang, Chen Wang, Zhigang Hu and Jie Zhang

Affiliation:

Keywords: Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides

Abstract: A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.

Cite this article as:

Pan Xiaoyan, Lu Wen, Li Pengfei, Wang Fang, Wang Chen, Hu Zhigang and Zhang Jie, A Novel and Facile Synthetic Approach for Tasigna, Medicinal Chemistry 2012; 8 (5) . https://dx.doi.org/10.2174/157340612802084207