Abstract
Dendrimers have found extensive convention in varied fields of biomedical engineering. Particularly, polyamidoamine (PAMAM) dendrimers have been found to have unique properties, and also interesting researches in the field of biomedical engineering have been recognized, when compared to other class of dendrimers. PAMAM dendrimers are biofriendly synthetic substances, and broadly studied dendrimers for biomedical applications, especially as therapeutic compositions. The focus of this review (citing 188 references) is on PAMAM dendrimer developments for biomedical applications, with prominence on conjugations for their extensive applications in the field of biomedical engineering and comparisons between classical (Tomalia PAMAM dendrimers) and novel (Baker-Huang PAMAM dendrimers) PAMAM dendrimers are also discussed by covering recent patents on PAMAM dendrimers. Finally, the use of PAMAM dendrimers in the field of proteomics, especially for use in phosphopeptide enrichment is presented. The future work points at the promises of developments.
Keywords: Patents, PAMAM dendrimers, PAMAM dendrimer-compositions, PAMAM dendrimer-conjugations, biomedical applications, disease-specific, Synthetic Strategies, Pharmacokinetics, biomacromolecules, Cytotoxicity.
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