Occupational disease is an important public health problem of the 21st century. Occupational disease still accounts for many preventable illnesses and injuries in the workplace. It is important to incorporate modern knowledge of disease epidemiology and cutting-edge diagnostic methods and treatment with the most recent developments in the management and prevention methods to better control work-related diseases and injuries. This book covers a selection of the common occupational diseases and injuries. It offers accurate, current information on the history, causes, diagnosis, management and prevention of several occupational diseases. Key features: - 14 chapters contributed by more than 30 experts in occupational and preventive medicine - Comprehensive treatment of the history, causes, diagnosis, management and prevention of many important occupational diseases (including asbestosis, silicosis, work-related asthma, occupational cancer, mesothelioma, arsenic, and other diseases.). - Each chapter highlights the latest research findings and cutting-edge technologies - References for further reading Modern Occupational Diseases: Diagnosis, Epidemiology, Management and Prevention serves as a useful guide for all readers interested in occupational diseases. The suggested readership includes trainees in occupational medicine, general practitioners, medical students, graduate students in public health programs, occupational health nurses, and professionals involved in occupational health and safety roles at public and private levels.

One of the most extraordinary characteristics of Mycobacterium tuberculosis infection is its capacity to remain within the host's tissues for a long period of time. There is an enormous reservoir of persons latently infected with tuberculosis (LTBI) estimated at about a third of the world's population. From this reservoir arise about 10 million new cases of active TB and more than two million deaths occur annually. Current Diagnosis of Infant Tuberculosis Infection covers problems concerning the diagnosis of LTBI, giving an overview of commercially available options and, unlike most reviews on this subject, also points out some tools currently under development. The Ebook provides comprehensive understandable, practice-oriented information on this subject, while keeping frontier research developments in consideration. It serves as an update to readers from universities to the research center and hospital staff - as well as a guide for helping clinicians to improve their diagnostic skills regarding TB infections in an endemic country (such as Brazil).

Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. It should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecular targets and rational drug design on this molecular basis should help in discovering early cancer biomarkers as well as novel therapeutic drugs. This book describes various cancer topics on a molecular level and integrates information on the relationship between causes of cancer, cancer cell biology, metastasis, cancer prevention and drug design. This book should prove to be an extraordinary reference text for students, physicians and oncologists.

Multiple drug resistance among bacteria has become a global issue with a considerable impact on the mortality associated with infectious diseases. This book is a detailed compilation of available knowledge on the surveillance and mechanisms of antibiotic resistance in various countries throughout the world. Readers will be updated on current information on the understanding of mechanisms involved in drug resistance and the geographical distribution of resistance determinant markers. This volume should be a useful guide for microbiologists and clinicians interested in designing antimicrobial therapies tailored for patients in specific geographical regions.

Mitochondria are multifunctional organelles that actively participate in the immune-inflammatory response in various pathologies. This volume updates readers on knowledge about mitochondria function. The editors have compiled six chapters about inflammation in its broadest sense, with contributions from active groups of cell biologists, infectologists and pathologists. The chapters in this volume focus on research related to five notable diseases: (1) two diseases (one bacterial and one viral) in which the exacerbation of the inflammatory response can lead to neuropathies: leprosy (one of the oldest diseases in the world) and Zika fever (a disease relatively new in Brazil) (2) three diseases (two bacterial and one viral) in which the exacerbation of the inflammatory response can lead to irreversible lung damage that can cause rapid death: tuberculosis, pneumonia and the most recent global disease, COVID- 19. New information about mitochondrial biology is presented, such as the effect of aerobic physical exercise as a stimulator for mitochondria multiplication, and the role of mitochondrial damage in inducing immune-inflammatory responses to pathogens. The contents shed light on mitochondrial biochemical pathways that could serve as potential therapeutic targets. This is an important reference for scholars (cell biologists, microbiologists) in universities, hospitals and scientific research centers working on biological and biomedical problems, and for health professionals involved in infection control.