Abstract
The following chapter outlines the current research status of studies exploring the generation of two essential ovarian cell types from stem cells: meiotic female germ cells from primordial germ cells to oocytes; and supporting somatic granulosa cells that are necessary for correct germ cell development and sex hormone production. Recent studies have reported the generation of both cell types in vitro and in vivo from a variety of sources, including somatic stem cells, induced pluripotent stem cells, and embryonic stem cells. While significant progress has been demonstrated, there are many areas that require further investigation. This review also discusses current research limitations and future prospects of this field within the context of regenerative medicine.
Keywords: Differentiation, follicle, folliculogenesis, granulosa cell, meiosis, oocyte, ovary, stem cells.
About this chapter
Cite this chapter as:
Derek Toms, Paul W. Dyce, Julang Li ;Differentiation Potential of Stem Cells into Ovarian Cells, Frontiers in Stem Cell and Regenerative Medicine Research (2016) 2: 116. https://doi.org/10.2174/9781681081830116020007
DOI https://doi.org/10.2174/9781681081830116020007 |
Print ISSN 2467-9593 |
Publisher Name Bentham Science Publisher |
Online ISSN 2352-7633 |