Frontiers in Stem Cell and Regenerative Medicine Research

Volume: 2

Differentiation Potential of Stem Cells into Ovarian Cells

Author(s): Derek Toms, Paul W. Dyce and Julang Li

Pp: 116-156 (41)

DOI: 10.2174/9781681081830116020007

* (Excluding Mailing and Handling)

Abstract

The following chapter outlines the current research status of studies exploring the generation of two essential ovarian cell types from stem cells: meiotic female germ cells from primordial germ cells to oocytes; and supporting somatic granulosa cells that are necessary for correct germ cell development and sex hormone production. Recent studies have reported the generation of both cell types in vitro and in vivo from a variety of sources, including somatic stem cells, induced pluripotent stem cells, and embryonic stem cells. While significant progress has been demonstrated, there are many areas that require further investigation. This review also discusses current research limitations and future prospects of this field within the context of regenerative medicine.


Keywords: Differentiation, follicle, folliculogenesis, granulosa cell, meiosis, oocyte, ovary, stem cells.

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      • 11. app/Models/ContentAccess.php:647
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59068240 and j.to_ip >=59068240 )) and ((j.from_date <= 1740496838 and j.to_date >= 1740496838 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8852) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59068240 and j.to_ip >=59068240 )) and ((j.from_date <= 1740496838 and j.to_date >= 1740496838 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8852) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59068240 and j.to_ip >=59068240 )) and ((j.from_date <= 1740496838 and j.to_date >= 1740496838 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8852)
      590μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1745 and `b`.`banner_from_date` <= 1740496838 and `b`.`banner_to_date` >= 1740496838 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.09msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1745
      • 3: 1740496838
      • 4: 1740496838
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='a6b74c70a4685aaf65059d1ec0698045'
      230μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    8Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        nwhjzA5ZevsiuwwWv15JMVR5aA7cc1mvyaHUFN36
        uc_cart_id
        a6b74c70a4685aaf65059d1ec0698045
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/8852" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/8852
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 15:20:38 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImFELzQxdWJzRWFBK2JJOHlTZzJlWFE9PSIsInZhbHVlIjoiWEZhdUpGSWRUN2g3UTNOTmwwMXVGd2NkSVZKS1B5cm9zWVBIbzdHQUNnNzd1SnlPTnlkMUdHb0N0N3h3T3liVG1EaURpclFvdjlGZFJ0ZW5XRVYxVHFRTndWb09OYWxvMjczQ201eGhNajgrdzQ5V29NYkFyNHV4VHZJMXpuYngiLCJtYWMiOiI0OTA3M2FhYjY3M2RiYmFjOTM4YTdiMDI5NjJmMTJjN2JkM2MxN2EzODE0Yjk4MjUxYWQwY2Y5NGY3NGY0OGI4IiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 03:20:38 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImFELzQxdWJzRWFBK2JJOHlTZzJlWFE9PSIsInZhbHVlIjoiWEZhdUpGSWRUN2g3UTNOTmwwMXVGd2NkSVZKS1B5cm9zWVBIbzdHQUNnNzd1SnlPTnlkMUdHb0N0N3h3T3liVG1EaURpc" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImJsWFJ4RWhrNllRWVEyUEEzU0xobUE9PSIsInZhbHVlIjoibGY5NXY1Qmh2TGpaNEkyL0lQQzRsRkhFbjBrMktob2x5UlgvWkhTNXNCYmF2dDFxRXpJaGc5UlVwVHFPUU1EYzM0bTRMQTNwTkFZeHJwRG9UR1ZlNkRqQWxtTExsRXRaYTlxVWJYMmg0VDlXMmoxSTNLSDRLb3NtTWJESS9vZ3EiLCJtYWMiOiJhMjJjNGFmZWZkMzMwM2Y4YWQwZmFiMzIwZjI1YWE4YzU4YzcxYmFlNzNmYzFmODkzNjJjYWZkODM1YmQxZTA3IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6ImJsWFJ4RWhrNllRWVEyUEEzU0xobUE9PSIsInZhbHVlIjoibGY5NXY1Qmh2TGpaNEkyL0lQQzRsRkhFbjBrMktob2x5UlgvWkhTNXNCYmF2dDFxRXpJaGc5UlV" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImFELzQxdWJzRWFBK2JJOHlTZzJlWFE9PSIsInZhbHVlIjoiWEZhdUpGSWRUN2g3UTNOTmwwMXVGd2NkSVZKS1B5cm9zWVBIbzdHQUNnNzd1SnlPTnlkMUdHb0N0N3h3T3liVG1EaURpclFvdjlGZFJ0ZW5XRVYxVHFRTndWb09OYWxvMjczQ201eGhNajgrdzQ5V29NYkFyNHV4VHZJMXpuYngiLCJtYWMiOiI0OTA3M2FhYjY3M2RiYmFjOTM4YTdiMDI5NjJmMTJjN2JkM2MxN2EzODE0Yjk4MjUxYWQwY2Y5NGY3NGY0OGI4IiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 03:20:38 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImFELzQxdWJzRWFBK2JJOHlTZzJlWFE9PSIsInZhbHVlIjoiWEZhdUpGSWRUN2g3UTNOTmwwMXVGd2NkSVZKS1B5cm9zWVBIbzdHQUNnNzd1SnlPTnlkMUdHb0N0N3h3T3liVG1EaURpc" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImJsWFJ4RWhrNllRWVEyUEEzU0xobUE9PSIsInZhbHVlIjoibGY5NXY1Qmh2TGpaNEkyL0lQQzRsRkhFbjBrMktob2x5UlgvWkhTNXNCYmF2dDFxRXpJaGc5UlVwVHFPUU1EYzM0bTRMQTNwTkFZeHJwRG9UR1ZlNkRqQWxtTExsRXRaYTlxVWJYMmg0VDlXMmoxSTNLSDRLb3NtTWJESS9vZ3EiLCJtYWMiOiJhMjJjNGFmZWZkMzMwM2Y4YWQwZmFiMzIwZjI1YWE4YzU4YzcxYmFlNzNmYzFmODkzNjJjYWZkODM1YmQxZTA3IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6ImJsWFJ4RWhrNllRWVEyUEEzU0xobUE9PSIsInZhbHVlIjoibGY5NXY1Qmh2TGpaNEkyL0lQQzRsRkhFbjBrMktob2x5UlgvWkhTNXNCYmF2dDFxRXpJaGc5UlV" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "nwhjzA5ZevsiuwwWv15JMVR5aA7cc1mvyaHUFN36" "uc_cart_id" => "a6b74c70a4685aaf65059d1ec0698045" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/8852" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 15:20:38GET/chapter/88521121910