Abstract
Cardiac dysfunction is a well-known complication of severe sepsis and septic shock. Septic cardiomyopathy is characterized by reduced cardiac output and left ventricular pressures and biventricular dilatation, resulting in systemic hypoperfusion and multi-organ failure. There is emerging evidence suggesting that mediators of septic cardiomyopathy include cardio-depressive cytokines, Toll-like receptor signaling, cardiomyocyte production of reactive oxygen species and nitric oxide, and dysregulated Ca2+ homeostasis. This chapter will review the current evidence describing the cellular and molecular mechanisms of septic cardiomyopathy.
Keywords: Ca2+, Cardiomyocyte, Cecal ligation and puncture, Cytokines, Endotoxemia, Heart, Nitric oxide, Reactive oxygen species, Sepsis, Toll-like receptors.
Related Journals
Current Dentistry
Current Traditional Medicine
Adolescent Psychiatry
New Emirates Medical Journal
Current Drug Targets - Cardiovascular & Hematological Disorders
Current Medicinal Chemistry - Cardiovascular & Hematological Agents
Current Cardiology Reviews
Current Hypertension Reviews
Cardiovascular & Hematological Agents in Medicinal Chemistry
Cardiovascular & Hematological Disorders-Drug Targets
Related Books
Andrology: Current and Future Developments
Male Infertility: An Integrative Manual of Western and Chinese Medicine
Recent Advances in Anesthesiology
Recent Advances in Anesthesiology
Recent Advances in Anesthesiology
Recent Advances in Anesthesiology
Awake Thoracic Surgery
The Anatomical Foundations of Regional Anesthesia and Acute Pain Medicine Macroanatomy Microanatomy Sonoanatomy Functional anatomy
Frontiers in Anti-infective Agents
Frontiers in Anti-infective Agents