Abstract
The ability of tumors to develop resistance to cytotoxic therapies has been a major obstacle in the clinical management of cancer. In addition, dose-limiting toxicity represents yet another impediment in the application of traditional therapeutics. To enhance the sensitivity of tumors to radio-therapeutics, researchers are increasingly turning to nitric oxide for its potential as a powerful adjuvant to existing therapies. Here, we review the aptitude of nitric oxide to serve as a radio-sensitizing, adjuvant therapeutic for the clinical management of cancer.
Keywords: Adjuvant therapy, cancer, nitric oxide, oncology, radiotherapy, therapeutic delivery.
About this chapter
Cite this chapter as:
Nicole J. Kenote, Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards, Mark A. Brown ;Nitric Oxide as an Adjuvant Therapeutic in the Clinical Management of Cancer, Frontiers in Anti-Cancer Drug Discovery (2014) 3: 191. https://doi.org/10.2174/9781608058846114030007
DOI https://doi.org/10.2174/9781608058846114030007 |
Print ISSN 1879-6656 |
Publisher Name Bentham Science Publisher |