Abstract
Familial non-medullary thyroid cancer is a clear clinical distinct entity characterized by multifocality and a more severe phenotype and is defined as the presence of two or more first-degree relatives affected by differentiated thyroid cancer of follicular origin. In some cases, the disease is associated with rare hereditary syndromes such as Carney complex, Werner syndromes, FAP and Cowden syndromes. However, in the majority of the cases, patients have thyroid cancer as the only disease manifestation. Several studies have tried to identify the genetic alteration(s) responsible for the development of FNMTC with promising results although none of the genes/loci identified accounts for the majority of cases of FNMTC and cannot be generalized to the larger at-risk population.
Keywords: FNMTC, Cowden disease, Werner syndrome, Carney complex, genetic loci.
Related Journals
Current Dentistry
Current Traditional Medicine
Adolescent Psychiatry
New Emirates Medical Journal
Current Radiopharmaceuticals
Recent Patents on Anti-Cancer Drug Discovery
Current Medicinal Chemistry - Anti-Cancer Agents
Current Cancer Therapy Reviews
Clinical Cancer Drugs
Anti-Cancer Agents in Medicinal Chemistry
Related Books
Andrology: Current and Future Developments
Male Infertility: An Integrative Manual of Western and Chinese Medicine
Recent Advances in Anesthesiology
Recent Advances in Anesthesiology
Recent Advances in Anesthesiology
Recent Advances in Anesthesiology
Awake Thoracic Surgery
The Anatomical Foundations of Regional Anesthesia and Acute Pain Medicine Macroanatomy Microanatomy Sonoanatomy Functional anatomy
Frontiers in Anti-infective Agents
Frontiers in Anti-infective Agents