Abstract
Aging is a universal, complicated biological process characterized by the progressive accumulation in an organism of diverse, deleterious changes with time that increase the chance of disease and death. Although the molecular mechanisms of aging remain elusive, increasing evidence suggests a critical role for free radicals and related reactive species, especially reactive oxygen species in the process of aging. This chapter provides an overview of the evidence from both experimental models and human subjects that supports an oxidative stress mechanism of aging.
Keywords: Aging, Antioxidant intervention, Catalase, Lifespan, Longevity, Nrf2, Oxidative stress, p66SHC, Paraoxonase 1, Reactive oxygen species, Sirtuins.
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