Abstract
A high enough level of bioavailability (BA) is a prerequisite in order for a drug to take effect. Absolute bioavailability is the fraction of a dose that reaches systemic circulation following oral administration. The key determinants of the systemically available drug level are the amount of the dose that enters the enterocytes and the fraction that escapes as a result of metabolism by the gut wall and/or the liver. Body biology, drug properties and formulation factors all influence the outcome. In silico, in vitro and in vivo models for drug screening have been developed and are able to provide predictions for human absorption in accordance with the degree of complexity of the model.
This chapter provides a summary of the drug properties and biological variables in the gastrointestinal tract that influence drug absorption, and summarises the key models that have been developed and are in use for screening and predicting intestinal drug absorption.
Related Journals
Current Psychopharmacology
Current Pharmaceutical Analysis
Current Drug Safety
Current Reviews in Clinical and Experimental Pharmacology
Current Clinical Pharmacology
Current Drug Research Reviews
Current Molecular Pharmacology
Current Neuropharmacology
Current Vascular Pharmacology
Current Pharmaceutical Design
Related Books
Bioactive Phytochemicals: Drug Discovery to Product Development
Biologically Active Natural Products from Asia and Africa: A Selection of Topics
Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features
Medical Applications of Beta-Glucan
Nanotechnology Driven Herbal Medicine for Burns: From Concept to Application
Postbiotics: Science, Technology and Applications
The Pharmaceutical Scientist Guide to Solution Kinetic Models Mathematical Description and Applications
Evidence-Based Research in Ayurveda against COVID-19 in Compliance with Standardized Protocols and Practices
Pharmaceutical Chemistry and Production: An Introductory Textbook
Pharmaceuticals for Targeting Coronaviruses