Theory in the Pathophysiology of Carcinogenesis

Integral Composite of Malignant Transformation and Metastatic Potentiality in Osteosarcoma

Author(s): Lawrence M. Agius

Pp: 28-34 (7)

DOI: 10.2174/978160805266011101010028

* (Excluding Mailing and Handling)

Abstract

A series of models as consequential steps in evolution in tumorigenesis is representative indices of the developmental history in establishment of the metastasizing potentiality of osteosarcoma. One might allow for the integral representations of further pathway generation in the evolution of the malignant lesion both in terms of the production of the malignant osteoid and also the proliferation of the malignant osteoblasts in the first instance. Only in recognition of such sequential series of hierarchal stages in development of the osteosarcoma, as both an evolved and de-evolved lesion complex, one can further realize the complexity of the consequences of spread of the tumor. It is to be further recognized the representation of stages in tumorigenesis as essential primary zones of consequence in that the osteosarcoma both evolves and de-evolves in its own right beyond simple dimensions of histogenetic principles as applicable to normal related tissues or organs.

In this sense, an integration of compound factors in pathogenesis is constitutive of the metastasizing potential for spread of a lesion that both microscopically and macroscopically involves the tumor origin and the consequence of steps in tumorigenesis as components of interaction and amplification of the malignant process.

Within overlapping systems of consequence, the pathogenesis of the osteosarcoma is constituted by the determining roles of establishment of a metastasizing potentiality beyond simple dynamics of a carcinogenic series of agents or agonists in tumorigenesis.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 58953283 and j.to_ip >=58953283 )) and ((j.from_date <= 1740775412 and j.to_date >= 1740775412 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 2450) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 58953283 and j.to_ip >=58953283 )) and ((j.from_date <= 1740775412 and j.to_date >= 1740775412 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 2450) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 58953283 and j.to_ip >=58953283 )) and ((j.from_date <= 1740775412 and j.to_date >= 1740775412 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 2450)
      1.1msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 960 and `b`.`banner_from_date` <= 1740775412 and `b`.`banner_to_date` >= 1740775412 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      10.85msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 960
      • 3: 1740775412
      • 4: 1740775412
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='0af7e5dc36f134e612e5c007a508b7e2'
      4.85msalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        sCvy4fQMWkOjeCutwJgcgS3nl6hOisQ2VzpPhRKB
        uc_cart_id
        0af7e5dc36f134e612e5c007a508b7e2
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/2450" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/2450
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Fri, 28 Feb 2025 20:43:32 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkV5WHJMaE9IcFBDb0FTd2NjZWpJb2c9PSIsInZhbHVlIjoiNExqeEdpSGptbE1uZWR2R0xzdVBsdFZXK1k2MnVKK1ZVZmFNRUhINVlTdUJvb3FKYldiT0dPNkx5aGxHZS80M2RzYlUyeHVFdkpYeVo0SGlwOTIzeGxqTk9Xd2N2SGZFSFBHN3JuUWpzajhTY0VHTWdKVGlWTStKcmw3UTNXVEciLCJtYWMiOiJjY2I5ZjA4ZjRlZDgzMTE1YThlNTZjNmY1NDNhYmE2MDIwMzE5YmRhOWZiZTA5ZmI4ZWExOGVhNjEwOGMxOTMzIiwidGFnIjoiIn0%3D; expires=Mon, 03 Mar 2025 08:43:32 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkV5WHJMaE9IcFBDb0FTd2NjZWpJb2c9PSIsInZhbHVlIjoiNExqeEdpSGptbE1uZWR2R0xzdVBsdFZXK1k2MnVKK1ZVZmFNRUhINVlTdUJvb3FKYldiT0dPNkx5aGxHZS80M2RzYlUye" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ijg3WGZsVWM0cm9hdGE0d1lnWWtVVFE9PSIsInZhbHVlIjoiTmJ0WG8xclNBczlXRFgxY1QveE1mMlEvcGExdjdGVTJCQTNUcmNUdENaNU9nVG5zSEpzK0ZRYTZYOFo4RXNPUkhWTVEyZlQ1NHpmV0RsQy9TNGlVUG4xN3M1cDh4aUlDaVpXc1dzVCtubWNLcDFXbEsyT0VucFQxUEJGZHF3UFUiLCJtYWMiOiI2MjBiZGYwMGNjYzIxMzVjZTgwMTA0ZmE3ODhjODkyZTM3YWQwZjU5YzY2M2E5NzI2OWU0N2Q0YzkzZWYzMjY4IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ijg3WGZsVWM0cm9hdGE0d1lnWWtVVFE9PSIsInZhbHVlIjoiTmJ0WG8xclNBczlXRFgxY1QveE1mMlEvcGExdjdGVTJCQTNUcmNUdENaNU9nVG5zSEpzK0ZRYTZ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkV5WHJMaE9IcFBDb0FTd2NjZWpJb2c9PSIsInZhbHVlIjoiNExqeEdpSGptbE1uZWR2R0xzdVBsdFZXK1k2MnVKK1ZVZmFNRUhINVlTdUJvb3FKYldiT0dPNkx5aGxHZS80M2RzYlUyeHVFdkpYeVo0SGlwOTIzeGxqTk9Xd2N2SGZFSFBHN3JuUWpzajhTY0VHTWdKVGlWTStKcmw3UTNXVEciLCJtYWMiOiJjY2I5ZjA4ZjRlZDgzMTE1YThlNTZjNmY1NDNhYmE2MDIwMzE5YmRhOWZiZTA5ZmI4ZWExOGVhNjEwOGMxOTMzIiwidGFnIjoiIn0%3D; expires=Mon, 03-Mar-2025 08:43:32 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkV5WHJMaE9IcFBDb0FTd2NjZWpJb2c9PSIsInZhbHVlIjoiNExqeEdpSGptbE1uZWR2R0xzdVBsdFZXK1k2MnVKK1ZVZmFNRUhINVlTdUJvb3FKYldiT0dPNkx5aGxHZS80M2RzYlUye" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ijg3WGZsVWM0cm9hdGE0d1lnWWtVVFE9PSIsInZhbHVlIjoiTmJ0WG8xclNBczlXRFgxY1QveE1mMlEvcGExdjdGVTJCQTNUcmNUdENaNU9nVG5zSEpzK0ZRYTZYOFo4RXNPUkhWTVEyZlQ1NHpmV0RsQy9TNGlVUG4xN3M1cDh4aUlDaVpXc1dzVCtubWNLcDFXbEsyT0VucFQxUEJGZHF3UFUiLCJtYWMiOiI2MjBiZGYwMGNjYzIxMzVjZTgwMTA0ZmE3ODhjODkyZTM3YWQwZjU5YzY2M2E5NzI2OWU0N2Q0YzkzZWYzMjY4IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ijg3WGZsVWM0cm9hdGE0d1lnWWtVVFE9PSIsInZhbHVlIjoiTmJ0WG8xclNBczlXRFgxY1QveE1mMlEvcGExdjdGVTJCQTNUcmNUdENaNU9nVG5zSEpzK0ZRYTZ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "sCvy4fQMWkOjeCutwJgcgS3nl6hOisQ2VzpPhRKB" "uc_cart_id" => "0af7e5dc36f134e612e5c007a508b7e2" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/2450" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-28 20:43:32GET/chapter/2450112193