Biomedical Applications of Perovskites: The Era of Bio-Piezoelectric Systems

Bone Tissue Engineering Using Perovskites in Regenerative Medicines

Author(s): Supriya Kumari, Joydeep Dutta, Leena Bhardwaj* and Vijay Kumar * .

Pp: 194-210 (17)

DOI: 10.2174/9789815256383124010013

* (Excluding Mailing and Handling)

Abstract

Regeneration of damaged bone tissue can be accomplished by mimicking the extracellular matrix (ECM) by generating porous topographic substrates. The process of bone tissue regeneration is supported by incorporating natural proteins and growth factors. The scaffolds developed for bone tissue regeneration support bone cell growth and induce bone-forming cells by using natural proteins and growth factors. Limitations associated with the referred approaches are improper scaffold stability, insufficient cell adhesion, proliferation, differentiation and mineralization with less expression of growth factor. Therefore, the use of engineered nanoparticles has been rapidly increasing in bone tissue engineering applications. The electrospray technique that produces nanomaterials has an advantage over other conventional methods as it generates particle sizes in the micro/nanoscale range. The size and charge of the particles are controlled by regulating the flow rate and electric voltage of the polymer solution. The unique properties of nanoparticles are the large surface area to volume ratio, small size and higher reactivity, making them a suitable substrate to be used in the field of biomedical engineering. These nanomaterials are extensively used for drug delivery as therapeutic agents, mimicking cellular components of extracellular matrix and restoring and improving the functions of damaged organs. The controlled and sustained release of encapsulated drugs, proteins, vaccines, growth factors, cells and nucleotides from nanoparticles has been well-established in nanomedicine. The present chapter provides insights into the preparation of nanoparticles by electrospraying and illustrates the use of nanoparticles in drug delivery for the purpose of bone tissue engineering.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59780576 and j.to_ip >=59780576 )) and ((j.from_date <= 1739847135 and j.to_date >= 1739847135 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 23161) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59780576 and j.to_ip >=59780576 )) and ((j.from_date <= 1739847135 and j.to_date >= 1739847135 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 23161) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59780576 and j.to_ip >=59780576 )) and ((j.from_date <= 1739847135 and j.to_date >= 1739847135 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 23161)
      570μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3761 and `b`.`banner_from_date` <= 1739847135 and `b`.`banner_to_date` >= 1739847135 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.36msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3761
      • 3: 1739847135
      • 4: 1739847135
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='ef7c930cde8e0c1fe5ce251853b74dae'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        Nq5rVcq48OGukKJgdyU47qsmZkHncfV93UVKzv5b
        uc_cart_id
        ef7c930cde8e0c1fe5ce251853b74dae
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/23161" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/23161
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 18 Feb 2025 02:52:15 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkJLUWFPVmgzL28wdWlmUEJBVVlQa0E9PSIsInZhbHVlIjoiajRWZUR4SEJMNmozK3lWY25uL205Z2JJSnFOZmpnWTFPUVhNNGVxUEl0cXh2M2FHTy9NSlIyRG44M0tFSU1oRXVxckhxNmFEVmVHcUtaTkw2d3ArOVVNZHhMM2VmSURxbnA2M2pwVzcwaE9QQjB1YzdNZXBMaHBhY0I3VGdRaXMiLCJtYWMiOiIwNjA4YjIxMzc5YjcyNjc2N2IzZDFmOGNjNmI1NGFlNWU0MDI1MzYyZmRhYmNlOTE5YzA2ZTQyMTQ5Mjc0ZTZkIiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 14:52:15 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkJLUWFPVmgzL28wdWlmUEJBVVlQa0E9PSIsInZhbHVlIjoiajRWZUR4SEJMNmozK3lWY25uL205Z2JJSnFOZmpnWTFPUVhNNGVxUEl0cXh2M2FHTy9NSlIyRG44M0tFSU1oRXVxckhxN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjVUL1MwekdaZk9RMElIbUlJNFpMS1E9PSIsInZhbHVlIjoiNytHOHBzZS8vcmNHRWZsb2pBdjEwVTJFWklQYUxWdmVpZ1UwT2VFR1p1czNPSXpqN01acXl1eWZnRXV2M1pLM3Vmd000SUlLZElpU1RiWlN6SjF4bXRxanlveWpDd0t0WmhvTE1hSVFOL20wbXloMEVlVkZkZE5wYkROT1JFSTgiLCJtYWMiOiJjNjkxYzM3ZTMzY2QyMTc2MzI1ODkyODY3Yzc5YWY3Nzk1M2M0ZWY3MGMyNmQyYzllODk2OWI4ZTc5OGRlOTE0IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjVUL1MwekdaZk9RMElIbUlJNFpMS1E9PSIsInZhbHVlIjoiNytHOHBzZS8vcmNHRWZsb2pBdjEwVTJFWklQYUxWdmVpZ1UwT2VFR1p1czNPSXpqN01acXl1eWZ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkJLUWFPVmgzL28wdWlmUEJBVVlQa0E9PSIsInZhbHVlIjoiajRWZUR4SEJMNmozK3lWY25uL205Z2JJSnFOZmpnWTFPUVhNNGVxUEl0cXh2M2FHTy9NSlIyRG44M0tFSU1oRXVxckhxNmFEVmVHcUtaTkw2d3ArOVVNZHhMM2VmSURxbnA2M2pwVzcwaE9QQjB1YzdNZXBMaHBhY0I3VGdRaXMiLCJtYWMiOiIwNjA4YjIxMzc5YjcyNjc2N2IzZDFmOGNjNmI1NGFlNWU0MDI1MzYyZmRhYmNlOTE5YzA2ZTQyMTQ5Mjc0ZTZkIiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 14:52:15 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkJLUWFPVmgzL28wdWlmUEJBVVlQa0E9PSIsInZhbHVlIjoiajRWZUR4SEJMNmozK3lWY25uL205Z2JJSnFOZmpnWTFPUVhNNGVxUEl0cXh2M2FHTy9NSlIyRG44M0tFSU1oRXVxckhxN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjVUL1MwekdaZk9RMElIbUlJNFpMS1E9PSIsInZhbHVlIjoiNytHOHBzZS8vcmNHRWZsb2pBdjEwVTJFWklQYUxWdmVpZ1UwT2VFR1p1czNPSXpqN01acXl1eWZnRXV2M1pLM3Vmd000SUlLZElpU1RiWlN6SjF4bXRxanlveWpDd0t0WmhvTE1hSVFOL20wbXloMEVlVkZkZE5wYkROT1JFSTgiLCJtYWMiOiJjNjkxYzM3ZTMzY2QyMTc2MzI1ODkyODY3Yzc5YWY3Nzk1M2M0ZWY3MGMyNmQyYzllODk2OWI4ZTc5OGRlOTE0IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjVUL1MwekdaZk9RMElIbUlJNFpMS1E9PSIsInZhbHVlIjoiNytHOHBzZS8vcmNHRWZsb2pBdjEwVTJFWklQYUxWdmVpZ1UwT2VFR1p1czNPSXpqN01acXl1eWZ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "Nq5rVcq48OGukKJgdyU47qsmZkHncfV93UVKzv5b" "uc_cart_id" => "ef7c930cde8e0c1fe5ce251853b74dae" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/23161" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-18 02:52:15GET/chapter/23161112192