Bioderived Materials: Harnessing Nature for Advanced Biochemical Handiwork

Designer Bio-inspired Hydrogels : A Key to Biomedical Challenges

Author(s): Naureen Khan, Vaibhav Shivhare, Rishabh Ahuja and Anita Dutt Konar

Pp: 61-91 (31)

DOI: 10.2174/9789815136869124010006

* (Excluding Mailing and Handling)

Abstract

Low molecular weight hydrogelators (LMOHGs) are extremely promising synthons, in the bottom-up fabrication of supramolecular soft materials. In recent years, significant contributions to Peptide-based hydrogels coined as Bioinspired fragments have been made. In this book chapter, our effort lies to module two different aspects: Firstly the underlying guidelines and principles for the tailoring of scaffolds that would lead to hydrogel formation and an overview of the role of non-covalent interactions/chemical functionalization that are the key components of various selfassembly processes. In the second section, we aim to bring together our recent achievements with designer assembly with respect to their self-aggregation behavior and applications mainly in the biomedical arena like drug delivery carrier design, antimicrobial, anti-inflammatory as well as wound healing properties. We anticipate that this article would provide a conceptual demonstration of the different approaches taken toward the construction of these task-specific designer hydrogels.

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      • 11. app/Models/ContentAccess.php:647
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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740471487 and j.to_date >= 1740471487 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 21682) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740471487 and j.to_date >= 1740471487 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 21682) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316312588 and j.to_ip >=316312588 )) and ((j.from_date <= 1740471487 and j.to_date >= 1740471487 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 21682)
      1.02msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3673 and `b`.`banner_from_date` <= 1740471487 and `b`.`banner_to_date` >= 1740471487 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      14.54msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3673
      • 3: 1740471487
      • 4: 1740471487
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='b7bef850b688cea61ef8a548abb877f0'
      300μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        4ogYlQPIHR8IWNOo4mNlU05uMjZN63AkKycNgEhC
        uc_cart_id
        b7bef850b688cea61ef8a548abb877f0
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/21682" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/21682
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 08:18:07 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlUrR0xLeitxSVJXWjgzQkJERm9HTXc9PSIsInZhbHVlIjoiTHI5Si82QzlVbkpPOExnSUFLSFJCQ3RzTU9aaUZqeUdWTHNicXZ3M2NVcURpR24vVVUzR2FMSGwrRFRrRzlBVWtQZlg1K3plZHVLR2dvYkQ4RlRUT1dBWm83ajhoTDdpdlJSUmlFd0loeFVxd0VQYTd6SDJoOFFTNVM3M2NqbUEiLCJtYWMiOiJjNjIyNmRkYWY4ZTE0NGY4M2M0YTE0MDZiMDYxODQ5Y2U5NjVlODRhMDZlYjczMmE3NGM3ZjJkZTM1ZDlkZmRjIiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 20:18:07 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IlUrR0xLeitxSVJXWjgzQkJERm9HTXc9PSIsInZhbHVlIjoiTHI5Si82QzlVbkpPOExnSUFLSFJCQ3RzTU9aaUZqeUdWTHNicXZ3M2NVcURpR24vVVUzR2FMSGwrRFRrRzlBVWtQZlg1K" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkF1V1pRZGNHSHVCN0lTbnZaQkNac0E9PSIsInZhbHVlIjoibHh1TFdNcEFIQ09PY1MrSld1V2FOYTViOXBNSk83amo1WDFZTE5BWXF0ditkZTlyRktnL0NqcDYwV1dvZ1pJbTNqVVExVEVDaEhrRm1xUjByV1VoZlBMWm50UENDV3pRSlV6YWdmZlJQTU91d1FjTFdtZkRoTlpiWUZRaFhmSkIiLCJtYWMiOiJhNzYzMTBjYjg4YWE3MDkwMzA5MDkzNzYwNGQyMWY0N2ViNDBkZmUwZjAwMThhOTQwZGI2MzBmNTQ5ZjlhYTU5IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IkF1V1pRZGNHSHVCN0lTbnZaQkNac0E9PSIsInZhbHVlIjoibHh1TFdNcEFIQ09PY1MrSld1V2FOYTViOXBNSk83amo1WDFZTE5BWXF0ditkZTlyRktnL0NqcDY" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlUrR0xLeitxSVJXWjgzQkJERm9HTXc9PSIsInZhbHVlIjoiTHI5Si82QzlVbkpPOExnSUFLSFJCQ3RzTU9aaUZqeUdWTHNicXZ3M2NVcURpR24vVVUzR2FMSGwrRFRrRzlBVWtQZlg1K3plZHVLR2dvYkQ4RlRUT1dBWm83ajhoTDdpdlJSUmlFd0loeFVxd0VQYTd6SDJoOFFTNVM3M2NqbUEiLCJtYWMiOiJjNjIyNmRkYWY4ZTE0NGY4M2M0YTE0MDZiMDYxODQ5Y2U5NjVlODRhMDZlYjczMmE3NGM3ZjJkZTM1ZDlkZmRjIiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 20:18:07 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IlUrR0xLeitxSVJXWjgzQkJERm9HTXc9PSIsInZhbHVlIjoiTHI5Si82QzlVbkpPOExnSUFLSFJCQ3RzTU9aaUZqeUdWTHNicXZ3M2NVcURpR24vVVUzR2FMSGwrRFRrRzlBVWtQZlg1K" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkF1V1pRZGNHSHVCN0lTbnZaQkNac0E9PSIsInZhbHVlIjoibHh1TFdNcEFIQ09PY1MrSld1V2FOYTViOXBNSk83amo1WDFZTE5BWXF0ditkZTlyRktnL0NqcDYwV1dvZ1pJbTNqVVExVEVDaEhrRm1xUjByV1VoZlBMWm50UENDV3pRSlV6YWdmZlJQTU91d1FjTFdtZkRoTlpiWUZRaFhmSkIiLCJtYWMiOiJhNzYzMTBjYjg4YWE3MDkwMzA5MDkzNzYwNGQyMWY0N2ViNDBkZmUwZjAwMThhOTQwZGI2MzBmNTQ5ZjlhYTU5IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IkF1V1pRZGNHSHVCN0lTbnZaQkNac0E9PSIsInZhbHVlIjoibHh1TFdNcEFIQ09PY1MrSld1V2FOYTViOXBNSk83amo1WDFZTE5BWXF0ditkZTlyRktnL0NqcDY" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "4ogYlQPIHR8IWNOo4mNlU05uMjZN63AkKycNgEhC" "uc_cart_id" => "b7bef850b688cea61ef8a548abb877f0" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/21682" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 08:18:07GET/chapter/21682112192