Abstract
When NPs are included in a Biological environment, they associate with a
large number of circulating proteins. As a result, they interact dynamically with each
other. This structure, which is defined as PC, affects the physical parameters of NPs
and causes positive or negative effects on them. PC composition is affected by many
properties of NPs, such as size, shape, and surface charge. Therefore, various surface
modifications on NPs directly affect PC formation and nature. Although many studies
have been carried out to understand the formation and composition of the resulting PC
structure, this area still maintains its popularity as a research topic. This review aims to
briefly give an idea about the effect of proteins in metabolism on NPs designed as
carrier molecules, the determination of these protein structures and the final fate of NPs
after PC formation.