Applied Computer-Aided Drug Design: Models and Methods

Anticancer Activity of Medicinal Plants Extract and Molecular Docking Studies

Author(s): Serap ÇETINKAYA and Burak TÜZÜN * .

Pp: 136-158 (23)

DOI: 10.2174/9789815179934123010007

* (Excluding Mailing and Handling)

Abstract

Molecular docking involves the interaction of a molecule with another place, usually in the protein structure, and simulating the placement of the molecule in the protein structure with certain score algorithms, taking into account many quantities, such as the electro-negativity of atoms, their positions to each other, and the conformation of the molecule to be inserted into the protein structure. Finally, the activity of the molecule with the highest percentage by mass against various cancer proteins was investigated according to the GC-MS results made on some medicinal and aromatic plants in order to set an example of molecular docking calculations.

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