Abstract
Liver cancer is the sixth most commonly diagnosed cancer and the fourth
leading cause of cancer death worldwide. Research over the last two decades has
revealed that medicinal plants have been used for the treatment of various neoplastic
diseases. Aloe vera is a ubiquitously naturally occurring and drought-resisting herbal
medicinal plant. Some reports suggest that Aloe vera possesses wound and burn
healing activities and anti-inflammatory as well as immunomodulatory effects. There
are no direct studies available on the role of the Aloe vera extract and its active
ingredient like aloe-emodin that modulates antiaging and anticancer activities,
particularly on immune cells as well as liver cancer cells. Aloe vera has many bioactive
compounds and pharmacological properties that may show an important role in liver
cancer prevention and treatment through the enhancement of regeneration, antiaging
activity, antioxidant activity, anticancer activity and modulation of genetic pathways.
Here, we discuss the study of the anticancer effect and modulation of expression of
various genes in response to Aloe vera in liver cancer.