Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications

Anatomy and Physiology of the Brain: Pathophysiology of Brain Tumor

Author(s): Amitha Muraleedharan* and Nikhil Ponnoor Anto

Pp: 1-33 (33)

DOI: 10.2174/9789815079722123010003

* (Excluding Mailing and Handling)

Abstract

The brain is an efficient processor of information. It is the most complex and sensitive organ in the body and is responsible for all functions of the body, including serving as the coordinating center for all sensations, mobility, emotions, and intellect. The magnitude of its myriad function is often realized usually when there is a disruption of the nervous system due to injury, disease, or inherited predispositions. Neuroscience is the field of study that endeavors to make sense of such diverse questions; at the same time, it points the way toward the effective treatment of dysfunctions. The two-way channel of information: findings from the laboratory leading towards stricter criteria for diagnosing brain disorders and more effective methods for treating them and in turn, the clinician's increasingly acute skills of diagnosis and observation that supply the research scientist with more precise data for study in the lab diligently expands the field of neuroscience. Tumors of the brain produce neurological manifestations through several mechanisms. Stronger hypotheses about the mechanism of a disease can point the way toward more effective treatments and new possibilities for a cure. In highly complex disorders of the brain, in which many factors genetic, environmental, epidemiological, even social and psychological—play a part, broadly based hypotheses are exceedingly useful. With the advancements in technology and a better understanding of brain anatomy and physiology, the quest to discover an efficient cure for life-threatening tumors of the brain is underway.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version173msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[18:05:26] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (91.3ms)time
  • Application (81.36ms)time
  • 1 x Booting (52.88%)
    91.30ms
    1 x Application (47.12%)
    81.36ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed24.96ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('314566706','',1,1739988326,1739988326) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739988326
      910μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('314566706','/chapter/20161',1,1739988326,1739988326)
      140μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) limit 1
      14.75msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 314566706
      • 1: 314566706
      • 2: 314566706
      • 3: 314566706
      • 4: 314566706
      • 5: 314566706
      • 6: 314566706
      • 7: 314566706
      • 8: 314566706
      • 9: 314566706
      • 10: 314566706
      • 11: 314566706
      • 12: 314566706
      • 13: 314566706
      • 14: 314566706
      • 15: 314566706
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '20161' limit 1
      380μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 20161
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '20161' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      940μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 20161
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '20161'
      310μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 20161
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 1205 limit 1
      280μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 1205
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1205) and se.ebook_id!=1205 and v.ebook_status='1'
      1.14msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1205) and se.ebook_id!=1205 and v.ebook_status='1' limit 10 offset 0
      1.06msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1205)
      400μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1205) limit 10 offset 0
      530μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 3567 and `e`.`is_uploaded` = 1
      540μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 3567
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 1205 and ebook_volume_id <> 3567 limit 1
      300μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 1205
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '20161' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      330μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '3567' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      290μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3567) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3567) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3567)
      620μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20161) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20161) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20161)
      700μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3567 and `b`.`banner_from_date` <= 1739988327 and `b`.`banner_to_date` >= 1739988327 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.09msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3567
      • 3: 1739988327
      • 4: 1739988327
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='997621626ae333f66b72c8f3abe54ea6'
      250μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        H6mJviE6ZmfrVSeAp0iJCzKl3kyTBiMmB3MSJ80M
        uc_cart_id
        997621626ae333f66b72c8f3abe54ea6
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/20161" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/20161
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IlVTVnFINGh3eFV5ZlowZzFJWmJkS0E9PSIsInZhbHVlIjoiaU1rL0wyVElVVjVzc282T3d3Zngyc1FJZ0haeVBuQ0hwbUI5U2pkTFNjTT0iLCJtYWMiOiI2MDU3Nzc4NTY3YTM0ZjNjZTI1ODAwNTM1MTcyNTM5MTU1ZDhlYmM2NzQxYjJlOWY4MjU4MDgwYzBlZGNjMWVmIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IlVTVnFINGh3eFV5ZlowZzFJWmJkS0E9PSIsInZhbHVlIjoiaU1rL0wyVElVVjVzc282T3d3Zngyc1FJZ0haeVBuQ0hwbUI5U2pkTFNjTT0iLCJtYWMiOiI2MDU3Nzc4NTY3YTM0" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 18:05:27 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjRCdnVaU3dKdFpoQ2lOd3ovU01lOHc9PSIsInZhbHVlIjoiOGl6eVdmUUZ3RC9CamNPSDZKcWRLMmJBaGJjbExHc09Eais5WldFM085bElhUVZhQkI4S01KSk5jVVRtV01zU3crUlV5anZzK3Z3ZlVvKzBpZjlmZ2VRS3Z0cUplV1hWbnEyZTNRMm5wV0U0ako5YVh2V1hBRUozL0tKbEFkTGoiLCJtYWMiOiJjMmJlOTQ4YWY1YTI4MGY2Yzc3MTU0YzFjNWJlNDFjZGNhY2EwZWExZTA1ZmRjMjNhNGEzMzFkOGZiOTI0OTFlIiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 06:05:27 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IjRCdnVaU3dKdFpoQ2lOd3ovU01lOHc9PSIsInZhbHVlIjoiOGl6eVdmUUZ3RC9CamNPSDZKcWRLMmJBaGJjbExHc09Eais5WldFM085bElhUVZhQkI4S01KSk5jVVRtV01zU3crUlV5a" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjlkUy9ZaEIrQjF4a0kvZUV5U3dYdGc9PSIsInZhbHVlIjoiZzdhMlVGQWl5NDBZdXMxRnpqK1BMRFNFOGdTZW5pclk3MkdlNFpxWFlCWGJ4K2svUmtQbGpaeVcvZ2ZZQVA5QmI5emlBQjBORVhQaXQxUjJJS04yMHVVSldiSmluQzVFaGpFbDUwam1KNGRqQVRqcXhKRng3aUF5ejNqZHViSFUiLCJtYWMiOiI0NDUyMmNlMjQ5ZmMzNTE5MGU5NmMwM2Q0OTcxOWUzMGY3YmJmMmQxM2E1ZGRmMTZiZWQ3OGYxNGZkODBjOGM3IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjlkUy9ZaEIrQjF4a0kvZUV5U3dYdGc9PSIsInZhbHVlIjoiZzdhMlVGQWl5NDBZdXMxRnpqK1BMRFNFOGdTZW5pclk3MkdlNFpxWFlCWGJ4K2svUmtQbGpaeVc" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjRCdnVaU3dKdFpoQ2lOd3ovU01lOHc9PSIsInZhbHVlIjoiOGl6eVdmUUZ3RC9CamNPSDZKcWRLMmJBaGJjbExHc09Eais5WldFM085bElhUVZhQkI4S01KSk5jVVRtV01zU3crUlV5anZzK3Z3ZlVvKzBpZjlmZ2VRS3Z0cUplV1hWbnEyZTNRMm5wV0U0ako5YVh2V1hBRUozL0tKbEFkTGoiLCJtYWMiOiJjMmJlOTQ4YWY1YTI4MGY2Yzc3MTU0YzFjNWJlNDFjZGNhY2EwZWExZTA1ZmRjMjNhNGEzMzFkOGZiOTI0OTFlIiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 06:05:27 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IjRCdnVaU3dKdFpoQ2lOd3ovU01lOHc9PSIsInZhbHVlIjoiOGl6eVdmUUZ3RC9CamNPSDZKcWRLMmJBaGJjbExHc09Eais5WldFM085bElhUVZhQkI4S01KSk5jVVRtV01zU3crUlV5a" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjlkUy9ZaEIrQjF4a0kvZUV5U3dYdGc9PSIsInZhbHVlIjoiZzdhMlVGQWl5NDBZdXMxRnpqK1BMRFNFOGdTZW5pclk3MkdlNFpxWFlCWGJ4K2svUmtQbGpaeVcvZ2ZZQVA5QmI5emlBQjBORVhQaXQxUjJJS04yMHVVSldiSmluQzVFaGpFbDUwam1KNGRqQVRqcXhKRng3aUF5ejNqZHViSFUiLCJtYWMiOiI0NDUyMmNlMjQ5ZmMzNTE5MGU5NmMwM2Q0OTcxOWUzMGY3YmJmMmQxM2E1ZGRmMTZiZWQ3OGYxNGZkODBjOGM3IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjlkUy9ZaEIrQjF4a0kvZUV5U3dYdGc9PSIsInZhbHVlIjoiZzdhMlVGQWl5NDBZdXMxRnpqK1BMRFNFOGdTZW5pclk3MkdlNFpxWFlCWGJ4K2svUmtQbGpaeVc" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "H6mJviE6ZmfrVSeAp0iJCzKl3kyTBiMmB3MSJ80M" "uc_cart_id" => "997621626ae333f66b72c8f3abe54ea6" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/20161" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 18:05:27GET/chapter/20161112192